IKZF3
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Zinc finger protein Aiolos also known as Ikaros family zinc finger protein 3 is a protein that in humans is encoded by the IKZF3 gene.[4][5][6]
Function
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At least six alternative transcripts encoding different isoforms have been described.[6]
Interactions
IKZF3 has been shown to interact with BCL2-like 1[7] and HRAS.[8]
References
- ↑ "Diseases that are genetically associated with IKZF3 view/edit references on wikidata".
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Morgan B, Sun L, Avitahl N, Andrikopoulos K, Ikeda T, Gonzales E, Wu P, Neben S, Georgopoulos K (Jun 1997). "Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation". EMBO J. 16 (8): 2004–13. doi:10.1093/emboj/16.8.2004. PMC 1169803
. PMID 9155026. - ↑ Hosokawa Y, Maeda Y, Takahashi E, Suzuki M, Seto M (Feb 2000). "Human aiolos, an ikaros-related zinc finger DNA binding protein: cDNA cloning, tissue expression pattern, and chromosomal mapping". Genomics. 61 (3): 326–9. doi:10.1006/geno.1999.5949. PMID 10552935.
- 1 2 "Entrez Gene: IKZF3 IKAROS family zinc finger 3 (Aiolos)".
- ↑ Rebollo A, Ayllón V, Fleischer A, Martínez CA, Zaballos A (December 2001). "The association of Aiolos transcription factor and Bcl-xL is involved in the control of apoptosis". J. Immunol. 167 (11): 6366–73. doi:10.4049/jimmunol.167.11.6366. PMID 11714801.
- ↑ Romero F, Martínez-A C, Camonis J, Rebollo A (June 1999). "Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization". EMBO J. 18 (12): 3419–30. doi:10.1093/emboj/18.12.3419. PMC 1171421. PMID 10369681.
Further reading
- Sun J, Matthias G, Mihatsch MJ, Georgopoulos K, Matthias P (February 2003). "Lack of the transcriptional coactivator OBF-1 prevents the development of systemic lupus erythematosus-like phenotypes in Aiolos mutant mice". J. Immunol. 170 (4): 1699–706. doi:10.4049/jimmunol.170.4.1699. PMID 12574333.
- Schmitt C, Tonnelle C, Dalloul A, et al. (2003). "Aiolos and Ikaros: regulators of lymphocyte development, homeostasis and lymphoproliferation.". Apoptosis. 7 (3): 277–84. doi:10.1023/A:1015372322419. PMID 11997672.
- Wang JH, Avitahl N, Cariappa A, et al. (1998). "Aiolos regulates B cell activation and maturation to effector state.". Immunity. 9 (4): 543–53. doi:10.1016/S1074-7613(00)80637-8. PMID 9806640.
- Kim J, Sif S, Jones B, et al. (1999). "Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes.". Immunity. 10 (3): 345–55. doi:10.1016/S1074-7613(00)80034-5. PMID 10204490.
- Koipally J, Renold A, Kim J, Georgopoulos K (1999). "Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes.". EMBO J. 18 (11): 3090–100. doi:10.1093/emboj/18.11.3090. PMC 1171390. PMID 10357820.
- Romero F, Martínez-A C, Camonis J, Rebollo A (1999). "Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization.". EMBO J. 18 (12): 3419–30. doi:10.1093/emboj/18.12.3419. PMC 1171421. PMID 10369681.
- Koipally J, Georgopoulos K (2000). "Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity.". J. Biol. Chem. 275 (26): 19594–602. doi:10.1074/jbc.M000254200. PMID 10766745.
- Perdomo J, Holmes M, Chong B, Crossley M (2001). "Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities.". J. Biol. Chem. 275 (49): 38347–54. doi:10.1074/jbc.M005457200. PMID 10978333.
- Rebollo A, Ayllón V, Fleischer A, et al. (2002). "The association of Aiolos transcription factor and Bcl-xL is involved in the control of apoptosis.". J. Immunol. 167 (11): 6366–73. doi:10.4049/jimmunol.167.11.6366. PMID 11714801.
- Liippo J, Nera KP, Veistinen E, et al. (2002). "Both normal and leukemic B lymphocytes express multiple isoforms of the human Aiolos gene.". Eur. J. Immunol. 31 (12): 3469–74. doi:10.1002/1521-4141(200112)31:12<3469::AID-IMMU3469>3.0.CO;2-G. PMID 11745366.
- Nakase K, Ishimaru F, Fujii K, et al. (2002). "Overexpression of novel short isoforms of Helios in a patient with T-cell acute lymphoblastic leukemia.". Exp. Hematol. 30 (4): 313–7. doi:10.1016/S0301-472X(01)00796-2. PMID 11937265.
- Koipally J, Georgopoulos K (2002). "A molecular dissection of the repression circuitry of Ikaros.". J. Biol. Chem. 277 (31): 27697–705. doi:10.1074/jbc.M201694200. PMID 12015313.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Antica M, Dubravcic K, Weber I, et al. (2007). "A search for a mutation of the Aiolos phosphorylation domain in lymphocytes from patients with leukemia.". Haematologica. 92 (2): 260–1. doi:10.3324/haematol.10753. PMID 17296582.
- Ghadiri A, Duhamel M, Fleischer A, et al. (2007). "Critical function of Ikaros in controlling Aiolos gene expression.". FEBS Lett. 581 (8): 1605–16. doi:10.1016/j.febslet.2007.03.025. PMID 17383641.
- Caballero R, Setien F, Lopez-Serra L, et al. (2007). "Combinatorial effects of splice variants modulate function of Aiolos.". J. Cell. Sci. 120 (Pt 15): 2619–30. doi:10.1242/jcs.007344. PMID 17646674.
External links
- IKZF3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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