RELB

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1ZK9, 1ZKA, 2V2T, 3DO7, 3JSS, 3JUZ, 3JV0, 3JV4, 3JV6, 4JGM, 4JHB

Identifiers

Aliases

RELB, I-REL, IREL, REL-B, RELB proto-oncogene, NF-kB subunit

External IDs

MGI: 103289 HomoloGene: 4747 GeneCards: RELB

Gene ontology
Molecular function	• DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • core promoter binding • transcription corepressor activity • transcription factor activity, sequence-specific DNA binding • chromatin binding • protein binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding
Cellular component	• cytoplasm • cytosol • I-kappaB/NF-kappaB complex • nucleoplasm • microtubule organizing center • cytoskeleton • nucleus
Biological process	• response to cytokine • antigen processing and presentation • regulation of transcription, DNA-templated • rhythmic process • regulation of transcription from RNA polymerase II promoter • myeloid dendritic cell differentiation • stimulatory C-type lectin receptor signaling pathway • negative regulation of transcription from RNA polymerase II promoter • T-helper 1 cell differentiation • negative regulation of interferon-beta production • circadian regulation of gene expression • transcription, DNA-templated • cellular response to osmotic stress • positive regulation of gene expression • NIK/NF-kappaB signaling • T-helper 1 type immune response • inflammatory response • negative regulation of transcription, DNA-templated • I-kappaB kinase/NF-kappaB signaling • positive regulation of transcription from RNA polymerase II promoter • innate immune response
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


5971


19698

Ensembl


ENSG00000104856


ENSMUSG00000002983

UniProt


Q01201


Q04863

RefSeq (mRNA)


NM_006509


NM_001290457 NM_009046

RefSeq (protein)


NP_006500.2


NP_001277386.1 NP_033072.2

Location (UCSC)

Chr 19: 45 – 45.04 Mb

Chr 7: 19.61 – 19.63 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Transcription factor RelB is a protein that in humans is encoded by the RELB gene.^[3]

Interactions

RELB has been shown to interact with NFKB2,^[4]^[5] NFKB1,^[4] and C22orf25.^[6]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Bours V, Burd PR, Brown K, Villalobos J, Park S, Ryseck RP, Bravo R, Kelly K, Siebenlist U (Feb 1992). "A novel mitogen-inducible gene product related to p50/p105-NF-kappa B participates in transactivation through a kappa B site". Molecular and Cellular Biology. 12 (2): 685–95. PMC 364259. PMID 1531086.
1 2 Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (Feb 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
↑ Thornburg NJ, Pathmanathan R, Raab-Traub N (Dec 2003). "Activation of nuclear factor-kappaB p50 homodimer/Bcl-3 complexes in nasopharyngeal carcinoma". Cancer Research. 63 (23): 8293–301. PMID 14678988.
↑ "Molecular Interaction Database".

Taylor JP, Pomerantz R, Bagasra O, Chowdhury M, Rappaport J, Khalili K, Amini S (Sep 1992). "TAR-independent transactivation by Tat in cells derived from the CNS: a novel mechanism of HIV-1 gene regulation". The EMBO Journal. 11 (9): 3395–403. PMC 556874. PMID 1505523.
Ruben SM, Klement JF, Coleman TA, Maher M, Chen CH, Rosen CA (May 1992). "I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity". Genes & Development. 6 (5): 745–60. doi:10.1101/gad.6.5.745. PMID 1577270.
Liu J, Perkins ND, Schmid RM, Nabel GJ (Jun 1992). "Specific NF-kappa B subunits act in concert with Tat to stimulate human immunodeficiency virus type 1 transcription". Journal of Virology. 66 (6): 3883–7. PMC 241175. PMID 1583734.
Biswas DK, Salas TR, Wang F, Ahlers CM, Dezube BJ, Pardee AB (Dec 1995). "A Tat-induced auto-up-regulatory loop for superactivation of the human immunodeficiency virus type 1 promoter". Journal of Virology. 69 (12): 7437–44. PMC 189681. PMID 7494249.
Jeang KT, Chun R, Lin NH, Gatignol A, Glabe CG, Fan H (Oct 1993). "In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor". Journal of Virology. 67 (10): 6224–33. PMC 238044. PMID 7690421.
Alcamí J, Laín de Lera T, Folgueira L, Pedraza MA, Jacqué JM, Bachelerie F, Noriega AR, Hay RT, Harrich D, Gaynor RB (Apr 1995). "Absolute dependence on kappa B responsive elements for initiation and Tat-mediated amplification of HIV transcription in blood CD4 T lymphocytes". The EMBO Journal. 14 (7): 1552–60. PMC 398242. PMID 7729429.
Majello B, De Luca P, Hagen G, Suske G, Lania L (Nov 1994). "Different members of the Sp1 multigene family exert opposite transcriptional regulation of the long terminal repeat of HIV-1". Nucleic Acids Research. 22 (23): 4914–21. doi:10.1093/nar/22.23.4914. PMC 523756. PMID 7800480.
Taylor JP, Pomerantz RJ, Oakes JW, Khalili K, Amini S (Jan 1995). "A CNS-enriched factor that binds to NF-kappa B and is required for interaction with HIV-1 tat". Oncogene. 10 (2): 395–400. PMID 7838536.
Westendorp MO, Shatrov VA, Schulze-Osthoff K, Frank R, Kraft M, Los M, Krammer PH, Dröge W, Lehmann V (Feb 1995). "HIV-1 Tat potentiates TNF-induced NF-kappa B activation and cytotoxicity by altering the cellular redox state". The EMBO Journal. 14 (3): 546–54. PMC 398112. PMID 7859743.
Scala G, Ruocco MR, Ambrosino C, Mallardo M, Giordano V, Baldassarre F, Dragonetti E, Quinto I, Venuta S (Mar 1994). "The expression of the interleukin 6 gene is induced by the human immunodeficiency virus 1 TAT protein". The Journal of Experimental Medicine. 179 (3): 961–71. doi:10.1084/jem.179.3.961. PMC 2191426. PMID 8113688.
Bours V, Azarenko V, Dejardin E, Siebenlist U (Jun 1994). "Human RelB (I-Rel) functions as a kappa B site-dependent transactivating member of the family of Rel-related proteins". Oncogene. 9 (6): 1699–702. PMID 8183565.
Deloukas P, Dauwerse JG, van Ommen GJ, van Loon AP (Feb 1994). "The human NFKB3 gene encoding the p65 subunit of transcription factor NF-kappa B is located on chromosome 11q12". Genomics. 19 (3): 592–4. doi:10.1006/geno.1994.1115. PMID 8188306.
Westendorp MO, Li-Weber M, Frank RW, Krammer PH (Jul 1994). "Human immunodeficiency virus type 1 Tat upregulates interleukin-2 secretion in activated T cells". Journal of Virology. 68 (7): 4177–85. PMC 236340. PMID 8207793.
Dobrzanski P, Ryseck RP, Bravo R (Mar 1993). "Both N- and C-terminal domains of RelB are required for full transactivation: role of the N-terminal leucine zipper-like motif". Molecular and Cellular Biology. 13 (3): 1572–82. PMC 359469. PMID 8441398.
Harhaj E, Blaney J, Millhouse S, Sun SC (Feb 1996). "Differential effects of I kappa B molecules on Tat-mediated transactivation of HIV-1 LTR". Virology. 216 (1): 284–7. doi:10.1006/viro.1996.0062. PMID 8615004.
Conant K, Ma M, Nath A, Major EO (Mar 1996). "Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes". Journal of Virology. 70 (3): 1384–9. PMC 189957. PMID 8627654.
Demarchi F, d'Adda di Fagagna F, Falaschi A, Giacca M (Jul 1996). "Activation of transcription factor NF-kappaB by the Tat protein of human immunodeficiency virus type 1". Journal of Virology. 70 (7): 4427–37. PMC 190376. PMID 8676466.
Beauparlant P, Kwon H, Clarke M, Lin R, Sonenberg N, Wainberg M, Hiscott J (Sep 1996). "Transdominant mutants of I kappa B alpha block Tat-tumor necrosis factor synergistic activation of human immunodeficiency virus type 1 gene expression and virus multiplication". Journal of Virology. 70 (9): 5777–85. PMC 190591. PMID 8709193.
Ramazzotti E, Vignoli M, Re MC, Furlini G, La Placa M (May 1996). "Enhanced nuclear factor-kappa B activation induced by tumour necrosis factor-alpha in stably tat-transfected cells is associated with the presence of cell-surface-bound Tat protein". AIDS. 10 (5): 455–61. doi:10.1097/00002030-199605000-00002. PMID 8724035.

PDB gallery

1zk9: NF-kB RelB forms an intertwined homodimer

1zka: NF-kB RelB forms an intertwined homodimer, Y300S mutant

Transcription factors and intracellular receptors

(1) Basic domains

(1.1) Basic leucine zipper (bZIP)	Activating transcription factor AATF 1 2 3 4 5 6 7 AP-1 c-Fos FOSB FOSL1 FOSL2 JDP2 c-Jun JUNB JunD BACH 1 2 BATF BLZF1 C/EBP α β γ δ ε ζ CREB 1 3 L1 CREM DBP DDIT3 GABPA HLF MAF B F G K NFE 2 L1 L2 L3 NFIL3 NRL NRF 1 2 3 XBP1

(1.2) Basic helix-loop-helix (bHLH)	ATOH1 AhR AHRR ARNT ASCL1 BHLH 2 3 9 ARNTL ARNTL ARNTL2 CLOCK EPAS1 FIGLA HAND 1 2 HES 5 6 HEY 1 2 L HES1 HIF 1A 3A ID 1 2 3 4 LYL1 MESP2 MXD4 MYCL1 MYCN Myogenic regulatory factors MyoD Myogenin MYF5 MYF6 Neurogenins 1 2 3 NeuroD 1 2 NPAS 1 2 3 OLIG 1 2 Pho4 Scleraxis SIM 1 2 TAL 1 2 Twist USF1

(1.3) bHLH-ZIP	AP-4 MAX MXD3 MITF MNT MLX MXI1 Myc SREBP 1 2

(1.4) NF-1	NFI A B C X SMAD R-SMAD 1 2 3 5 9 I-SMAD 6 7 4)

(1.5) RF-X	RFX 1 2 3 4 5 6 ANK

(1.6) Basic helix-span-helix (bHSH)	AP-2 α β γ δ ε

(2) Zinc finger DNA-binding domains

(2.1) Nuclear receptor (Cys₄)

subfamily 1	Thyroid hormone α β CAR FXR LXR α β PPAR α β/δ γ PXR RAR α β γ ROR α β γ Rev-ErbA α β VDR

subfamily 2	COUP-TF (I II Ear-2 HNF4 α γ PNR RXR α β γ Testicular receptor 2 4 TLX

subfamily 3	Steroid hormone Androgen Estrogen α β Glucocorticoid Mineralocorticoid Progesterone Estrogen related α β γ

subfamily 4	NUR NGFIB NOR1 NURR1

subfamily 5	LRH-1 SF1

subfamily 6	GCNF

subfamily 0	DAX1 SHP

(2.2) Other Cys₄

GATA
- 1
- 2
- 3
- 4
- 5
- 6
MTA
- 1
- 2
- 3
TRPS1

(2.3) Cys₂His₂

General transcription factors
- TFIIA
- TFIIB
- TFIID
- TFIIE
  - 1
  - 2
- TFIIF
- 1
- 2
  - TFIIH
  - 1
  - 2
  - 4
  - 2I
  - 3A
  - 3C1
  - 3C2

ATBF1
BCL
- 6
- 11A
- 11B
CTCF
E4F1
EGR
- 1
- 2
- 3
- 4
ERV3
GFI1
GLI-Krüppel family
- 1
- 2
- 3
- REST
- S1
- S2
- YY1
HIC
- 1
- 2
HIVEP
- 1
- 2
- 3
IKZF
- 1
- 2
- 3
ILF
- 2
- 3
KLF
- 1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 9
- 10
- 11
- 12
- 13
- 14
- 15
- 17
MTF1
MYT1
OSR1
PRDM9
SALL
- 1
- 2
- 3
- 4
SP
- 1
- 2
- 4
- 7
- 8
TSHZ3
WT1
Zbtb7
- 7A
- 7B
ZBTB
- 11
- 16
- 17
- 20
- 32
- 33
- 40
zinc finger
- 3
- 7
- 9
- 10
- 19
- 22
- 24
- 33B
- 34
- 35
- 41
- 43
- 44
- 51
- 74
- 143
- 146
- 148
- 165
- 202
- 217
- 219
- 238
- 239
- 259
- 267
- 268
- 281
- 295
- 300
- 318
- 330
- 346
- 350
- 365
- 366
- 384
- 423
- 451
- 452
- 471
- 593
- 638
- 644
- 649
- 655

(2.4) Cys₆

HIVEP1

(2.5) Alternating composition

AIRE
DIDO1
GRLF1
ING
- 1
- 2
- 4
JARID
- 1A
- 1B
- 1C
- 1D
- 2
JMJD1B

(2.6) WRKY

WRKY

(3) Helix-turn-helix domains

(3.1) Homeodomain	ARX CDX 1 2 CRX CUTL1 DBX 1 2 DLX 3 4 5 EMX 1 2 EN 1 2 FHL 1 2 3 HESX1 HHEX HLX Homeobox A1 A2 A3 A4 A5 A7 A9 A10 A11 A13 B1 B2 B3 B4 B5 B6 B7 B8 B9 B13 C4 C5 C6 C8 C9 C10 C11 C12 C13 D1 D3 D4 D8 D9 D10 D11 D12 D13 HOPX IRX 1 2 3 4 5 6 MKX LMX 1A 1B MEIS 1 2 MEOX2 MNX1 MSX 1 2 NANOG NKX 2-1 2-2 2-3 2-5 3-1 3-2 6-1 6-2 NOBOX PBX 1 2 3 PHF 1 3 6 8 10 16 17 20 21A PHOX 2A 2B PITX 1 2 3 POU domain PIT-1 BRN-3: A B C Octamer transcription factor: 1 2 3/4 6 7 11 OTX 1 2 PDX1 SATB2 SHOX2 SIX 1 2 3 4 5 VAX1 ZEB 1 2

(3.2) Paired box	PAX 1 2 3 4 5 6 7 8 9 PRRX 1 2 RAX

(3.3) Fork head / winged helix	E2F 1 2 3 4 5 FOX proteins A1 A2 A3 C1 C2 D3 D4 E1 E3 F1 G1 H1 I1 J1 J2 K1 K2 L2 M1 N1 N3 O1 O3 O4 P1 P2 P3 P4

(3.4) Heat shock factors	HSF 1 2 4

(3.5) Tryptophan clusters	ELF 2 4 5 EGF ELK 1 3 4 ERF ETS 1 2 ERG SPIB ETV 1 4 5 6 FLI1 Interferon regulatory factors 1 2 3 4 5 6 7 8 MYB MYBL2

(3.6) TEA domain	transcriptional enhancer factor 1 2 3 4

(4) β-Scaffold factors with minor groove contacts

(4.1) Rel homology region	NF-κB NFKB1 NFKB2 REL RELA RELB NFAT C1 C2 C3 C4 5

(4.2) STAT	STAT 1 2 3 4 5 6

(4.3) p53	p53 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF TP63

(4.4) MADS box	Mef2 A B C D SRF

(4.6) TATA-binding proteins	TBP TBPL1

(4.7) High-mobility group	BBX HMGB 1 2 3 4 HMGN 1 2 3 4 HNF 1A 1B LEF1 SOX 1 2 3 4 5 6 8 9 10 11 12 13 14 15 18 21 SRY SSRP1 TCF 3 4 TOX 1 2 3 4

(4.9) Grainyhead	TFCP2

(4.10) Cold-shock domain	CSDA YBX1

(4.11) Runt	CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1

(0) Other transcription factors

(0.2) HMGI(Y)	HMGA 1 2 HBP1

(0.3) Pocket domain	Rb RBL1 RBL2

(0.5) AP-2/EREBP-related factors	Apetala 2 EREBP B3

(0.6) Miscellaneous	ARID 1A 1B 2 3A 3B 4A CAP IFI 16 35 MLL 2 3 T1 MNDA NFY A B C Rho/Sigma

see also transcription factor/coregulator deficiencies

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RELB

Interactions

See also

References

Further reading