FOSL1

FOSL1
Identifiers
Aliases	FOSL1, FRA, FRA1, fra-1, FOS like 1, AP-1 trancription factor subunit, FOS like 1, AP-1 transcription factor subunit
External IDs	MGI: 107179 HomoloGene: 3967 GeneCards: FOSL1
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding • protein binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding Cellular component • cytosol • intracellular membrane-bounded organelle • neuron projection • presynaptic membrane • nucleus Biological process • cellular response to extracellular stimulus • response to cytokine • regulation of transcription, DNA-templated • response to organic cyclic compound • vitellogenesis • regulation of transcription from RNA polymerase II promoter • response to progesterone • female pregnancy • response to corticosterone • response to mechanical stimulus • response to virus • positive regulation of sequence-specific DNA binding transcription factor activity • placenta blood vessel development • in utero embryonic development • learning • positive regulation of DNA-templated transcription, initiation • chemotaxis • response to gravity • cellular defense response • positive regulation of cell cycle • positive regulation of cell proliferation • positive regulation of apoptotic process • response to cAMP • response to hydrogen peroxide • response to drug • positive regulation of transcription from RNA polymerase II promoter • negative regulation of cell proliferation • pri-miRNA transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8061	14283
Ensembl	ENSG00000175592	ENSMUSG00000024912
UniProt	P15407	P48755
RefSeq (mRNA)	NM_001300844 NM_001300855 NM_001300856 NM_001300857 NM_005438	NM_010235
RefSeq (protein)	NP_001287773.1 NP_001287784.1 NP_001287785.1 NP_001287786.1 NP_005429.1	NP_034365.1
Location (UCSC)	Chr 11: 65.89 – 65.9 Mb	Chr 19: 5.45 – 5.46 Mb
PubMed search	[1]	[2]
Wikidata

Fos-related antigen 1 (FRA1) is a protein that in humans is encoded by the FOSL1 gene.^[3][4]

Function

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.^[4]

Interactions

FOSL1 has been shown to interact with USF1 (human gene)^[5] and C-jun.^[5]

See also

• AP-1 (transcription factor)

References

Further reading

External links

• FOSL1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
• FactorBook FOSL1

This article incorporates text from the United States National Library of Medicine, which is in the public domain.