Mothers against decapentaplegic homolog 6

SMAD6
Identifiers
Aliases	SMAD6, AOVD2, HsT17432, MADH6, MADH7, SMAD family member 6
External IDs	OMIM: 602931 MGI: 1336883 HomoloGene: 4079 GeneCards: SMAD6
Gene ontology Molecular function • DNA binding • R-SMAD binding • type I transforming growth factor beta receptor binding • co-SMAD binding • I-SMAD binding • transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity • transcription factor activity, sequence-specific DNA binding • chromatin binding • type I activin receptor binding • metal ion binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • protein binding • identical protein binding • transcription regulatory region DNA binding • ubiquitin protein ligase binding Cellular component • cytoplasm • cytosol • transcription factor complex • intracellular • protein complex • nucleus Biological process • ureteric bud development • heart valve development • regulation of transcription, DNA-templated • ventricular septum development • zygotic specification of dorsal/ventral axis • negative regulation of SMAD protein complex assembly • response to laminar fluid shear stress • negative regulation of apoptotic process • negative regulation of transforming growth factor beta receptor signaling pathway • coronary vasculature development • BMP signaling pathway • transcription, DNA-templated • negative regulation of pathway-restricted SMAD protein phosphorylation • response to estrogen • negative regulation of BMP signaling pathway • aorta development • cell-substrate adhesion • immune response • transforming growth factor beta receptor signaling pathway • fat cell differentiation • negative regulation of cell proliferation • mitral valve morphogenesis • positive regulation of pri-miRNA transcription from RNA polymerase II promoter • negative regulation of ossification • pulmonary valve morphogenesis • outflow tract septum morphogenesis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4091	17130
Ensembl	ENSG00000137834	ENSMUSG00000036867
UniProt	O43541	O35182
RefSeq (mRNA)	NM_001142861 NM_005585	NM_008542
RefSeq (protein)	NP_005576.3	NP_032568.3
Location (UCSC)	Chr 15: 66.7 – 66.78 Mb	Chr 9: 63.95 – 64.02 Mb
PubMed search	[1]	[2]
Wikidata

SMAD family member 6, also known as SMAD6, is a protein that in humans is encoded by the SMAD6 gene.^[3]

SMAD6 is a protein that, as its name describes, is a homolog of the Drosophila gene "mothers against decapentaplegic". It belongs to the SMAD family of proteins, which belong to the TGFβ superfamily of modulators. Like many other TGFβ family members SMAD6 is involved in cell signalling. It acts as a regulator of TGFβ family (such as bone morphogenetic proteins) activity by competing with SMAD4 and preventing the transcription of SMAD4's gene products. There are two known isoforms of this protein.

Nomenclature

The SMAD proteins are homologs of both the drosophila protein, mothers against decapentaplegic (MAD) and the C. elegans protein SMA. The name is a combination of the two. During Drosophila research, it was found that a mutation in the gene MAD in the mother repressed the gene decapentaplegic in the embryo. The phrase "Mothers against" was added since mothers often form organizations opposing various issues, e.g., Mothers Against Drunk Driving, or MADD; and based on a tradition of such unusual naming within the gene research community.^[4]

Interactions

Mothers against decapentaplegic homolog 6 has been shown to interact with:

• HOXC8,^[5]
• MAP3K7,^[6][7]
• Mothers against decapentaplegic homolog 7,^[8]
• PIAS4,^[9] and
• STRAP.^[10]

References

Further reading