NFYC

NFYC
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases NFYC, CBF-C, CBFC, H1TF2A, HAP5, HSM, NF-YC, nuclear transcription factor Y subunit gamma
External IDs MGI: 107901 HomoloGene: 7440 GeneCards: NFYC
RNA expression pattern




More reference expression data
Orthologs
Species Human Mouse
Entrez

4802

18046

Ensembl

ENSG00000066136

ENSMUSG00000032897

UniProt

Q13952

P70353

RefSeq (mRNA)

NM_001048168
NM_001277095
NM_008692

RefSeq (protein)

NP_001041633.1
NP_001264024.1
NP_032718.2

Location (UCSC) Chr 1: 40.69 – 40.77 Mb Chr 4: 120.76 – 120.83 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Nuclear transcription factor Y subunit gamma is a protein that in humans is encoded by the NFYC gene.[3][4][5]

Function

The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit C, forms a tight dimer with the B subunit (NFYB), a prerequisite for subunit A (NFYA) association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants. Additional regulation, preliminarily supported by the EST database, may be represented by alternative splicing in this subunit.[5]

Two microRNAs; miR-30c and miR-30e are located within introns of the nfyc gene. These microRNAs are actively transcribed in human insulin-producing beta cells in the pancreatic islets that also show high expression of nfyc and CDH1 genes. The expression of these intronic microRNAs is essential for maintaining the differentiated phenotype of human islet beta cells. Inhibition of miR-30 family microRNAs induces epithelial-mesenchymal transition of human pancreatic islet cells.[6]

Interactions

NFYC has been shown to interact with Myc.[7]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Sinha S, Maity SN, Seldin MF, de Crombrugghe B (Feb 1997). "Chromosomal assignment and tissue expression of CBF-C/NFY-C, the third subunit of the mammalian CCAAT-binding factor". Genomics. 37 (2): 260–3. doi:10.1006/geno.1996.0555. PMID 8921405.
  4. Bellorini M, Zemzoumi K, Farina A, Berthelsen J, Piaggio G, Mantovani R (Aug 1997). "Cloning and expression of human NF-YC". Gene. 193 (1): 119–25. doi:10.1016/S0378-1119(97)00109-1. PMID 9249075.
  5. 1 2 "Entrez Gene: NFYC nuclear transcription factor Y, gamma".
  6. Joglekar MV, Patil D, Joglekar VM, Rao GV, Reddy DN, Mitnala S, Shouche Y, Hardikar AA (September–October 2009). "The miR-30 family microRNAs confer epithelial phenotype to human pancreatic cells". Islets. 1 (2): 137–147. doi:10.4161/isl.1.2.9578. PMID 21099261.
  7. Taira T, Sawai M, Ikeda M, Tamai K, Iguchi-Ariga SM, Ariga H (August 1999). "Cell cycle-dependent switch of up-and down-regulation of human hsp70 gene expression by interaction between c-Myc and CBF/NF-Y". J. Biol. Chem. 274 (34): 24270–9. doi:10.1074/jbc.274.34.24270. PMID 10446203.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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