Germ cell nuclear factor

NR6A1
Identifiers
Aliases	NR6A1, CT150, GCNF, GCNF1, NR61, RTR, hGCNF, hRTR, nuclear receptor subfamily 6 group A member 1
External IDs	OMIM: 602778 MGI: 1352459 HomoloGene: 36308 GeneCards: NR6A1
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding • protein homodimerization activity • transcription factor activity, sequence-specific DNA binding • zinc ion binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • metal ion binding • steroid hormone receptor activity • RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding Cellular component • nucleoplasm • nucleus • transcription factor complex Biological process • regulation of transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • gamete generation • spermatogenesis • transcription initiation from RNA polymerase II promoter • cell proliferation • positive regulation of transcription from RNA polymerase II promoter • steroid hormone mediated signaling pathway • intracellular steroid hormone receptor signaling pathway • transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2649	14536
Ensembl	ENSG00000148200	ENSMUSG00000063972
UniProt	Q15406	Q64249
RefSeq (mRNA)	NM_001278546 NM_001489 NM_033334 NM_033335	NM_001159548 NM_001159549 NM_010264
RefSeq (protein)	NP_001265475.1 NP_001480.3 NP_201591.2 NP_201591.2	NP_001153020.1 NP_034394.1
Location (UCSC)	Chr 9: 124.52 – 124.77 Mb	Chr 2: 38.72 – 38.93 Mb
PubMed search	[1]	[2]
Wikidata

The germ cell nuclear factor (GCNF), also known as RTR (retinoid receptor-related testis-associated receptor) or NR6A1 (nuclear receptor subfamily 6, group A, member 1), is a protein that in humans is encoded by the NR6A1 gene.^[3][4] GCNF is a member of the nuclear receptor family of intracellular transcription factors .

In adults, GCNH is expressed mainly in the germ cells of gonads and is involved in the regulation of embryogenesis and germ cell differentiation.^[5]

Its expression pattern suggests that it may be involved in neurogenesis and germ cell development. The protein can homodimerize and bind DNA, but in vivo targets have not been identified. The gene expresses three alternatively spliced transcript variants.^[6]

References

Further reading

External links

• NR6A1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)