TBPL1

TBPL1
Identifiers
Aliases TBPL1, MGC:8389, MGC:9620, STUD, TLF, TLP, TRF2, TATA-box binding protein like 1
External IDs MGI: 1339946 HomoloGene: 3577 GeneCards: TBPL1
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

9519

237336

Ensembl

ENSG00000028839

ENSMUSG00000071359

UniProt

P62380
Q7Z6T9

P62340

RefSeq (mRNA)

NM_004865
NM_001253676

NM_011603

RefSeq (protein)

NP_001240605.1
NP_004856.1

NP_035733.1

Location (UCSC) Chr 6: 133.95 – 133.99 Mb Chr 10: 22.7 – 22.73 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

TATA box-binding protein-like protein 1 is a protein that in humans is encoded by the TBPL1 gene.[3][4][5][6]

Function

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that serves the same function as TBP and substitutes for TBP at some promoters that are not recognized by TFIID. It is essential for spermiogenesis and believed to be important in expression of developmentally regulated genes.[6]

Interactions

TBPL1 has been shown to interact with GTF2A1.[7][8]

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. ↑ Ohbayashi T, Kishimoto T, Makino Y, Shimada M, Nakadai T, Aoki T, Kawata T, Niwa S, Tamura T (Feb 1999). "Isolation of cDNA, chromosome mapping, and expression of the human TBP-like protein". Biochemical and Biophysical Research Communications. 255 (1): 137–42. doi:10.1006/bbrc.1999.0159. PMID 10082669.
  4. ↑ Rabenstein MD, Zhou S, Lis JT, Tjian R (Apr 1999). "TATA box-binding protein (TBP)-related factor 2 (TRF2), a third member of the TBP family". Proceedings of the National Academy of Sciences of the United States of America. 96 (9): 4791–6. doi:10.1073/pnas.96.9.4791. PMC 21770Freely accessible. PMID 10220372.
  5. ↑ Chong JA, Moran MM, Teichmann M, Kaczmarek JS, Roeder R, Clapham DE (Apr 2005). "TATA-binding protein (TBP)-like factor (TLF) is a functional regulator of transcription: reciprocal regulation of the neurofibromatosis type 1 and c-fos genes by TLF/TRF2 and TBP". Molecular and Cellular Biology. 25 (7): 2632–43. doi:10.1128/MCB.25.7.2632-2643.2005. PMC 1061635Freely accessible. PMID 15767669.
  6. 1 2 "Entrez Gene: TBPL1 TBP-like 1".
  7. ↑ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948Freely accessible. PMID 17353931.
  8. ↑ Teichmann M, Wang Z, Martinez E, Tjernberg A, Zhang D, Vollmer F, Chait BT, Roeder RG (Nov 1999). "Human TATA-binding protein-related factor-2 (hTRF2) stably associates with hTFIIA in HeLa cells". Proceedings of the National Academy of Sciences of the United States of America. 96 (24): 13720–5. doi:10.1073/pnas.96.24.13720. PMC 24131Freely accessible. PMID 10570139.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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