Hydroxyflutamide
 | |
| Identifiers | |
|---|---|
| |
| Synonyms | Hydroxyniphtholide, hydroxyniftolide; α,α,α-trifluoro-2-methyl-4'-nitro-m-lactotoluidide |
| CAS Number | 52806-53-8 |
| PubChem (CID) | 91649 |
| IUPHAR/BPS | 2862 |
| ChemSpider | 82752 |
| UNII | 31D90UKP5Y |
| KEGG | C14204 |
| ChEBI | CHEBI:43064 |
| ChEMBL | CHEMBL491 |
| ECHA InfoCard | 100.169.708 |
| Chemical and physical data | |
| Formula | C11H11F3N2O4 |
| Molar mass | 292.21125 g/mol |
| 3D model (Jmol) | Interactive image |
| |
| |
Hydroxyflutamide (HF, OHF) (developmental code name SCH-16423), or 2-hydroxyflutamide, is a non-steroidal antiandrogen.[1][2] It is the major active metabolite of flutamide.[2] It is reported to possess an IC50 of 700 nM for the androgen receptor (AR), about 4-fold less than that of bicalutamide.[3]
See also
References
- ↑ Serra, C; Sandor, NL; Jang, H; Lee, D; Toraldo, G; Guarneri, T; Wong, S; Zhang, A; Guo, W; Jasuja, R; Bhasin, S (2013). "The effects of testosterone deprivation and supplementation on proteasomal and autophagy activity in the skeletal muscle of the male mouse: Differential effects on high-androgen responder and low-androgen responder muscle groups". Endocrinology. 154 (12): 4594–606. doi:10.1210/en.2013-1004. PMC 3836062
. PMID 24105483. - 1 2 Singh, Shankar; Gauthier, Sylvain; Labrie, Fernand (2000). "Androgen Receptor Antagonists (Antiandrogens) Structure-Activity Relationships". Current Medicinal Chemistry. 7 (2): 211–247. doi:10.2174/0929867003375371. ISSN 0929-8673.
- ↑ Furr BJ (1995). "Casodex: preclinical studies and controversies". Annals of the New York Academy of Sciences. 761: 79–96. PMID 7625752.
This article is issued from Wikipedia - version of the 9/1/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.