YK-11
| Identifiers | |
|---|---|
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| Synonyms | YK11; ((17α,20E)-17,20-[(1-methoxyethylidene)bis(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid methyl ester |
| CAS Number | 1370003-76-1 |
| PubChem (CID) | 119058028 |
| ChemSpider | 52085570 |
| UNII | Z9748J6B0R |
| Chemical and physical data | |
| Formula | C25H34O6 |
| Molar mass | 430.541 g/mol |
| 3D model (Jmol) | Interactive image |
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YK-11 is a synthetic, steroidal selective androgen receptor modulator (SARM).[1][2] It is a gene-selective partial agonist of the androgen receptor (AR) and does not induce the physical interaction between the NTD/AF1 and LBD/AF2 (known as the N/C interaction), which is required for full transactivation of the AR.[1][2] The drug has anabolic activity in vitro in C2C12 myoblasts and shows greater potency than dihydrotestosterone (DHT) in this regard.[2]
See also
References
- 1 2 Kanno Y, Hikosaka R, Zhang SY, Inoue Y, Nakahama T, Kato K, Yamaguchi A, Tominaga N, Kohra S, Arizono K, Inouye Y (2011). "(17α,20E)-17,20-[(1-methoxyethylidene)bis(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid methyl ester (YK11) is a partial agonist of the androgen receptor". Biol. Pharm. Bull. 34 (3): 318–23. PMID 21372378.
- 1 2 3 Kanno Y, Ota R, Someya K, Kusakabe T, Kato K, Inouye Y (2013). "Selective androgen receptor modulator, YK11, regulates myogenic differentiation of C2C12 myoblasts by follistatin expression". Biol. Pharm. Bull. 36 (9): 1460–5. PMID 23995658.
External links
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