Inocoterone
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| Clinical data | |
|---|---|
| Routes of administration | Topical |
| Identifiers | |
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| CAS Number |
83646-97-3 83646-86-0 (acetate) |
| PubChem (CID) | 11776794 |
| ChemSpider | 9951477 |
| UNII | Q35F31B844 |
| Chemical and physical data | |
| Formula | C16H24O2 |
| Molar mass | 248.36056 g/mol |
| 3D model (Jmol) | Interactive image |
| |
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Inocoterone (INN), or as inocoterone acetate (USAN) (developmental code names RU-882, RU-38882), also known as 17β-hydroxy-2,5-seco-A-dinorestr-9-en-5-one [acetate], is a non-steroidal antiandrogen that was developed in 1985 for topical administration but was never marketed.[1][2][3] It was investigated for the treatment of acne but showed only modest (albeit statistically significant) efficacy in clinical trials.[4][5] A reduction of 26% of lesions was observed in males treated with the drug after 16 weeks (~3.7 months).[5][6] However, this is notably far less than that achieved with other agents such as benzoyl peroxide or antibiotics, which produce 50–75% reductions within 2 months.[6] Similar poor results with the topical route have disappointingly been found for other antiandrogens such as cyproterone acetate and spironolactone.[6]
See also
References
- ↑ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 686–. ISBN 978-1-4757-2085-3.
- ↑ P. Michael Conn (23 July 2010). Techniques in Confocal Microscopy. Academic Press. pp. 215–. ISBN 978-0-12-384659-4.
- ↑ Annual Reports in Medicinal Chemistry. Academic Press. 2 September 1987. pp. 358–. ISBN 978-0-08-058366-2.
- ↑ Leo Plouffe, Jr; Botros R. M. B. Rizk (25 June 2015). Androgens in Gynecological Practice. Cambridge University Press. pp. 84–. ISBN 978-1-316-29887-9.
- 1 2 Lookingbill, D. P. (1992). "Inocoterone and acne. The effect of a topical antiandrogen: results of a multicenter clinical trial". Archives of Dermatology. 128 (9): 1197–1200. doi:10.1001/archderm.128.9.1197. ISSN 0003-987X.
- 1 2 3 Richard A. Helms; David J. Quan (2006). Textbook of Therapeutics: Drug and Disease Management. Lippincott Williams & Wilkins. pp. 211–. ISBN 978-0-7817-5734-8.