Mestanolone

Mestanolone

Clinical data
Trade names	Andoron, Notandron
AHFS/Drugs.com	International Drug Names
Pregnancy category	US: X (Contraindicated)
Routes of administration	Oral
ATC code	none
Legal status
Legal status	DEA Schedule III (US)
Pharmacokinetic data
Bioavailability	99% oral
Protein binding	yes
Metabolism	Hepatic
Biological half-life	?
Excretion	Renal
Identifiers
IUPAC name (5α,17β)-17-hydroxy-17-methylandrostan-3-one
Synonyms	(5S,8R,9S,10S,13S,14S,17S)-17-hydroxy-10,13,17-trimethyl-2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-3-one
CAS Number	521-11-9 N
PubChem (CID)	10633
ChemSpider	10187 Y
UNII	S712YZ168E Y
KEGG	D01533 Y
ChEMBL	CHEMBL261514 Y
Chemical and physical data
Formula	C20H32O2
Molar mass	304.467 g/mol
3D model (Jmol)	Interactive image
SMILES O=C2C[C@@H]1CC[C@@H]3[C@@H]([C@@]1(C)CC2)CC[C@]4([C@H]3CC[C@@]4(O)C)C
InChI InChI=1S/C20H32O2/c1-18-9-6-14(21)12-13(18)4-5-15-16(18)7-10-19(2)17(15)8-11-20(19,3)22/h13,15-17,22H,4-12H2,1-3H3/t13-,15+,16-,17-,18-,19-,20-/m0/s1 Y Key:WYZDXEKUWRCKOB-YDSAWKJFSA-N Y
NY (what is this?)  (verify)

Mestanolone (brand names Andoron, Notandron) is the 17α-methylated version of dihydrotestosterone (DHT).^[1] The systematic name of mestanolone is: 17β-hydroxy-17α-methylandrost-3-one.^[2] It is an orally bioavailable androgenic steroid that is highly androgenic while only slightly anabolic. It is incapable of aromatization and is not an agonist of the progesterone receptor.

Dosage Information

Dosages range from 10 mg to 30 mg a day for males. Women should avoid Mestanolone for it is very androgenic. Long-term use, more than 12 weeks, should be avoided do to hepatoxicity. Since Mestanolone is unable to convert to estrogen, it is very useful during cutting phases or when one wishes to avoid excess weight gain.

Synonyms

Mestanolone is also known as methylandrostanolone or 17alpha-methylandrostanolone.^[3]

References