Nonsteroidal
Nonsteroidal is a term used to describe a compound that is not a steroid and to indicate as such.
It is used in the name of nonsteroidal anti-inflammatory drugs (NSAIDs) to distinguish them from corticosteroids as a class of anti-inflammatory agents.[1]
Nonsteroidal is also used to describe steroidergic drugs that are not steroid derivatives.[2][3] Examples include the following:[2][3]
- Estrogens: benzestrol, bifluranol, DBE, diethylstilbestrol (stilbestrol), dienestrol, fosfestrol, hexestrol (dihydroxystilbestrol), methallenestril, methestrol, methestrol dipropionate, paroxypropione, prinaberel, and triphenylethylene, as well as many xenoestrogens
- SERMs: acolbifene, afimoxifene, arzoxifene, bazedoxifene, broparestrol, chlorotrianisene, clomifene, clomifenoxide, cyclofenil, droloxifene, enclomifene, endoxifen, ethamoxytriphetol, fispemifene, idoxifene, lasofoxifene, levormeloxifene, miproxifene, nafoxidine, nitromifene, ormeloxifene, ospemifene, panomifene, pipendoxifene, raloxifene, sivifene, tamoxifen, tesmilifene, toremifene, trioxifene, zindoxifene, zuclomifene
- Antiandrogens: apalutamide, bicalutamide, cimetidine, darolutamide, DIMP, enzalutamide, EPI-001, EPI-506, flutamide, hydroxyflutamide, inocoterone, ketoconazole, nilutamide, orteronel, RU-58642, RU-58841, and topilutamide
- SARMs: AC-262,356, acetothiolutamide, andarine, BMS-564,929, enobosarm (ostarine), GW-501516, JNJ-28330835, LGD-2226, LGD-3303, LGD-4033, S-23, and S-40503
- Miscellaneous: tanaproget (progestogen), finerenone (antimineralocorticoid), esaxerenone (antimineralocorticoid), apararenone (antimineralocorticoid), AZD5423 (glucocorticoid), AL082D06 (antiglucocorticoid), mapracorat (SGRM), and Org 214007-0 (SGRM)
References
- ↑ Buer JK (Oct 2014). "Origins and impact of the term 'NSAID'". Inflammopharmacology. 22 (5): 263–7. doi:10.1007/s10787-014-0211-2. PMID 25064056.
- 1 2 Edward J. Pavlik (6 December 2012). Estrogens, Progestins, and Their Antagonists: Health Issues. Springer Science & Business Media. pp. 166–. ISBN 978-1-4612-4096-9.
- 1 2 Thomas Nogrady Professor of Medicinal Chemistry Concordia University (Emeritus); Donald F. Weaver Canada Research Chair and Professor of Medicine and Chemistry Dalhousie University (27 July 2005). Medicinal Chemistry : A Molecular and Biochemical Approach: A Molecular and Biochemical Approach. Oxford University Press, USA. pp. 322–. ISBN 978-0-19-802645-7.
Further reading
- Buijsman, Rogier; Hermkens, Pedro; Rijn, Rachel; Stock, H.; Teerhuis, N. (2005). "Non-Steroidal Steroid Receptor Modulators". Current Medicinal Chemistry. 12 (9): 1017–1075. doi:10.2174/0929867053764671. ISSN 0929-8673.
- Hermkens PH, Kamp S, Lusher S, Veeneman GH (2006). "Non-steroidal steroid receptor modulators". IDrugs. 9 (7): 488–94. PMID 16821162.
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