ACKR3

ACKR3
Identifiers
Aliases	ACKR3, CMKOR1, CXC-R7, CXCR-7, CXCR7, GPR159, RDC-1, RDC1, atypical chemokine receptor 3
External IDs	MGI: 109562 HomoloGene: 22419 GeneCards: ACKR3
Targeted by Drug
plerixafor[1]
Gene ontology Molecular function • C-X-C chemokine receptor activity • G-protein coupled receptor activity • coreceptor activity • C-X-C chemokine binding • signal transducer activity • chemokine binding • scavenger receptor activity • protein binding Cellular component • cytoplasm • integral component of membrane • recycling endosome • endosome • intracellular membrane-bounded organelle • membrane • plasma membrane • cell surface • early endosome • perinuclear region of cytoplasm • clathrin-coated pit Biological process • G-protein coupled receptor signaling pathway • chemokine-mediated signaling pathway • receptor internalization • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage • vasculogenesis • multicellular organism development • chemotaxis • cell adhesion • angiogenesis • positive regulation of ERK1 and ERK2 cascade • viral process • xenophagy • signal transduction • positive regulation of defense response to virus by host Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	57007	12778
Ensembl	ENSG00000144476	ENSMUSG00000044337
UniProt	P25106	P56485
RefSeq (mRNA)	NM_001047841 NM_020311	NM_001271607 NM_007722
RefSeq (protein)	NP_064707.1	NP_001258536.1 NP_031748.2
Location (UCSC)	Chr 2: 236.57 – 236.58 Mb	Chr 1: 90.2 – 90.22 Mb
PubMed search	[2]	[3]
Wikidata

Atypical chemokine receptor 3 also known as C-X-C chemokine receptor type 7 (CXCR-7) and G-protein coupled receptor 159 (GPR159) is a protein that in humans is encoded by the ACKR3 gene.^[4][5]

This gene encodes a member of the G protein-coupled receptor family. This protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP) and was considered to be an orphan receptor. It is now classified as a chemokine receptor able to bind the chemokines CXCL12/SDF-1 and CXCL11. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. Whereas some reports claim that the receptor induces signaling following ligand binding, recent findings in zebrafish suggest that CXCR7 functions primarily by sequestering the chemokine CXCL12.^[5]

However, another recent study has provided evidence that ligand binding to CXCR7 activates MAP kinases through Beta-arrestins, and thus has functions beyond ligand sequestration.^[6]

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.