CCL12

Ccl12
Identifiers
Aliases chemokine (C-C motif) ligand 12MCP-5Scya12
External IDs HomoloGene: 2245 GeneCards:
Orthologs
Species Human Mouse
Entrez

20293

6347

Ensembl

ENSMUSG00000035352

ENSG00000108691

UniProt

Q62401

P13500

RefSeq (mRNA)

NM_011331

NM_002982

RefSeq (protein)

NP_035461.2

NP_002973.1

Location (UCSC) n/a n/a
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Chemokine (C-C motif) ligand 12 (CCL12) is a small cytokine belonging to the CC chemokine family that has been described in mice. It is also known as monocyte chemotactic protein 5 (MCP-5) and, due to its similarity with the human chemokine MCP-1, sometimes it is called MCP-1-related chemokine. CCL12 specifically attracts eosinophils, monocytes and lymphocytes.[3] This chemokine is found predominantly in lymph nodes and thymus under normal conditions, and its expression can be hugely induced in macrophages.[3][4] It is thought to coordinate cell movements during early allergic reactions, and immune response to pathogens. The gene for CCL12 is found in a cluster of CC chemokines on mouse chromosome 11.[4]

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. 1 2 Jia G, Gonzalo J, Lloyd C, Kremer L, Lu L, Martinez-A C, Wershil B, Gutierrez-Ramos J (1996). "Distinct expression and function of the novel mouse chemokine monocyte chemotactic protein-5 in lung allergic inflammation". J Exp Med. 184 (5): 1939–51. doi:10.1084/jem.184.5.1939. PMC 2192876Freely accessible. PMID 8920881.
  4. 1 2 Sarafi M, Garcia-Zepeda E, MacLean J, Charo I, Luster A (1997). "Murine monocyte chemoattractant protein (MCP)-5: a novel CC chemokine that is a structural and functional homologue of human MCP-1". J Exp Med. 185 (1): 99–109. doi:10.1084/jem.185.1.99. PMC 2196097Freely accessible. PMID 8996246.



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