IL2RA

IL2RA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Z92, 2B5I, 2ERJ, 3IU3, 3NFP
Identifiers
Aliases	IL2RA, CD25, IDDM10, IL2R, TCGFR, p55, IMD41, interleukin 2 receptor subunit alpha
External IDs	MGI: 96549 HomoloGene: 360 GeneCards: IL2RA
Genetically Related Diseases
rheumatoid arthritis, type 1 diabetes mellitus, multiple sclerosis, Crohn's disease, alopecia areata[1]
Gene ontology Molecular function • interleukin-2 binding • interleukin-2 receptor activity • drug binding • Ras guanyl-nucleotide exchange factor activity Cellular component • integral component of membrane • membrane • plasma membrane • cell surface • external side of plasma membrane • intracellular Biological process • Notch signaling pathway • positive regulation of T cell differentiation • regulation of T cell tolerance induction • inflammatory response to antigenic stimulus • negative regulation of defense response to virus • immune system process • activation-induced cell death of T cells • negative regulation of lymphocyte proliferation • MAPK cascade • T cell homeostasis • regulation of T cell homeostatic proliferation • cell surface receptor signaling pathway • negative regulation of T cell proliferation • negative regulation of immune response • immune response • interleukin-2-mediated signaling pathway • positive regulation of T cell proliferation • cell proliferation • inflammatory response • negative regulation of inflammatory response • positive regulation of activated T cell proliferation • apoptotic process • positive regulation of GTPase activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3559	16184
Ensembl	ENSG00000134460	ENSMUSG00000026770
UniProt	P01589	P01590
RefSeq (mRNA)	NM_000417 NM_001308242 NM_001308243	NM_008367
RefSeq (protein)	NP_000408.1 NP_001295171.1 NP_001295172.1	NP_032393.3
Location (UCSC)	Chr 10: 6.01 – 6.06 Mb	Chr 2: 11.64 – 11.69 Mb
PubMed search	[2]	[3]
Wikidata

Interleukin-2 receptor alpha chain is a protein that in humans is encoded by the IL2RA gene.^[4]

The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is currently unknown.^[5]

Infection by the protozoan Trypanosoma cruzi causes Chagas disease, characterized by a reduction in the amount of IL2RA expressed on the surface of immune cells. This leads to chronic immune suppression, becoming increasingly severe over the course of many years and ultimately resulting in death if left untreated.

References

Further reading

PDB gallery
1z92: structure of interleukin-2 with its alpha receptor  2b5i: cytokine receptor complex  2erj: Crystal structure of the heterotrimeric interleukin-2 receptor in complex with interleukin-2