IFNAR1

IFNAR1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases IFNAR1, AVP, IFN-alpha-REC, IFNAR, IFNBR, IFRC, interferon alpha and beta receptor subunit 1
External IDs MGI: 107658 HomoloGene: 524 GeneCards: IFNAR1
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

3454

15975

Ensembl

ENSG00000142166

ENSMUSG00000022967

UniProt

P17181

P33896

RefSeq (mRNA)

NM_000629

NM_010508

RefSeq (protein)

NP_000620.2

NP_034638.2

Location (UCSC) Chr 21: 33.32 – 33.36 Mb Chr 16: 91.49 – 91.51 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Interferon-alpha/beta receptor alpha chain is a protein that in humans is encoded by the IFNAR1 gene.[3][4]

Function

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor.[4]

Interactions

IFNAR1 has been shown to interact with:

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Novick D, Cohen B, Rubinstein M (Jun 1994). "The human interferon alpha/beta receptor: characterization and molecular cloning". Cell. 77 (3): 391–400. doi:10.1016/0092-8674(94)90154-6. PMID 8181059.
  4. 1 2 "Entrez Gene: IFNAR1 interferon (alpha, beta and omega) receptor 1".
  5. Abramovich C, Yakobson B, Chebath J, Revel M (Jan 1997). "A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor". EMBO J. 16 (2): 260–6. doi:10.1093/emboj/16.2.260. PMC 1169633Freely accessible. PMID 9029147.
  6. Li X, Leung S, Kerr IM, Stark GR (Apr 1997). "Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling". Mol. Cell. Biol. 17 (4): 2048–56. doi:10.1128/mcb.17.4.2048. PMC 232052Freely accessible. PMID 9121453.
  7. Uddin S, Chamdin A, Platanias LC (Oct 1995). "Interaction of the transcriptional activator Stat-2 with the type I interferon receptor". J. Biol. Chem. 270 (42): 24627–30. doi:10.1074/jbc.270.42.24627. PMID 7559568.
  8. Yan H, Krishnan K, Greenlund AC, Gupta S, Lim JT, Schreiber RD, Schindler CW, Krolewski JJ (Mar 1996). "Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein". EMBO J. 15 (5): 1064–74. PMC 450004Freely accessible. PMID 8605876.
  9. Richter MF, Duménil G, Uzé G, Fellous M, Pellegrini S (Sep 1998). "Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1". J. Biol. Chem. 273 (38): 24723–9. doi:10.1074/jbc.273.38.24723. PMID 9733772.
  10. Kumar KG, Varghese B, Banerjee A, Baker DP, Constantinescu SN, Pellegrini S, Fuchs SY (Jul 2008). "Basal ubiquitin-independent internalization of interferon alpha receptor is prevented by Tyk2-mediated masking of a linear endocytic motif". J. Biol. Chem. 283 (27): 18566–72. doi:10.1074/jbc.M800991200. PMC 2441555Freely accessible. PMID 18474601.

Further reading


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