CCL14
| chemokine (C-C motif) ligand 14 | |
|---|---|
| Identifiers | |
| Symbol | CCL14 |
| Alt. symbols | SCYA14, HCC-1, HCC-3, NCC-2, SCYL2, CKb1, MCIF |
| Entrez | 6358 |
| HUGO | 10612 |
| OMIM | 601392 |
| RefSeq | NM_032962 |
| UniProt | Q16627 |
| Other data | |
| Locus | Chr. 17 q11.2 |
Chemokine (C-C motif) ligand 14 (CCL14) is a small cytokine belonging to the CC chemokine family. It is also commonly known as HCC-1. It is produced as a protein precursor that is processed to generate a mature active protein containing 74 amino acids that and is 46% identical in amino acid composition to CCL3 and CCL4. This chemokine is expressed in various tissues including spleen, bone marrow, liver, muscle, and gut.[1] CCL14 activates monocytes, but does not induce their chemotaxis. Human CCL14 is located on chromosome 17 within a cluster of other chemokines belonging to the CC family.[2]
References
- ↑ Schulz-Knappe et al., HCC-1, a novel chemokine from human plasma. J. Exp. Med., 1996, 183: 295-299.
- ↑ Naruseet al., A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. Genomics, 1996, 34: 236-240.
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