IL22RA1
| IL22RA1 | |||||||||||||||||
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| Identifiers | |||||||||||||||||
| Aliases | IL22RA1, CRF2-9, IL22R, IL22R1, interleukin 22 receptor subunit alpha 1 | ||||||||||||||||
| External IDs | MGI: 2663588 HomoloGene: 10943 GeneCards: IL22RA1 | ||||||||||||||||
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| Species | Human | Mouse | |||||||||||||||
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| Location (UCSC) | Chr 1: 24.12 – 24.14 Mb | Chr 4: 135.73 – 135.75 Mb | |||||||||||||||
| PubMed search | [1] | [2] | |||||||||||||||
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| View/Edit Human | View/Edit Mouse |
Interleukin 22 receptor, alpha 1 is a protein that in humans is encoded by the IL22RA1 gene.[3]
Function
The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10RB/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36.
References
Further reading
- Bleicher, L.; De Moura, P. R.; Watanabe, L.; Colau, D.; Dumoutier, L.; Renauld, J. C.; Polikarpov, I. (2008). "Crystal structure of the IL-22/IL-22R1 complex and its implications for the IL-22 signaling mechanism". FEBS Letters. 582 (20): 2985–2992. doi:10.1016/j.febslet.2008.07.046. PMID 18675809.
- Jones, B. C.; Logsdon, N. J.; Walter, M. R. (2008). "Structure of IL-22 Bound to Its High-Affinity IL-22R1 Chain". Structure. 16 (9): 1333–1344. doi:10.1016/j.str.2008.06.005. PMC 2637415
. PMID 18599299. - De Moura, P. R.; Watanabe, L.; Bleicher, L.; Colau, D.; Dumoutier, L.; Lemaire, M. M.; Renauld, J. C.; Polikarpov, I. (2009). "Crystal structure of a soluble decoy receptor IL-22BP bound to interleukin-22". FEBS Letters. 583 (7): 1072–1077. doi:10.1016/j.febslet.2009.03.006. PMID 19285080.
- Dumoutier, L.; De Meester, C.; Tavernier, J.; Renauld, J. -C. (2009). "New Activation Modus of STAT3: A TYROSINE-LESS REGION OF THE INTERLEUKIN-22 RECEPTOR RECRUITS STAT3 BY INTERACTING WITH ITS COILED-COIL DOMAIN". Journal of Biological Chemistry. 284 (39): 26377–26384. doi:10.1074/jbc.M109.007955. PMC 2785325. PMID 19632985.
- Wu, P. W.; Li, J.; Kodangattil, S. R.; Luxenberg, D. P.; Bennett, F.; Martino, M.; Collins, M.; Dunussi-Joannopoulos, K.; Gill, D. S.; Wolfman, N. M.; Fouser, L. A. (2008). "IL-22R, IL-10R2, and IL-22BP Binding Sites Are Topologically Juxtaposed on Adjacent and Overlapping Surfaces of IL-22". Journal of Molecular Biology. 382 (5): 1168–1183. doi:10.1016/j.jmb.2008.07.046. PMID 18675824.
- Meng, S.; Gui, Q.; Xu, Q.; Lu, K.; Jiao, X.; Fan, J.; Ge, B.; Ke, Y.; Zhang, S.; Wu, J.; Wang, C. (2010). "Association of Shp2 with Phosphorylated IL-22R1 is Required for Interleukin-22-induced MAP Kinase Activation". Journal of Molecular Cell Biology. 2 (4): 223–230. doi:10.1093/jmcb/mjq017. PMC 2948820. PMID 20671117.
- Kotenko, S. V.; Izotova, L. S.; Mirochnitchenko, O. V.; Esterova, E.; Dickensheets, H.; Donnelly, R. P.; Pestka, S. (2000). "Identification of the Functional Interleukin-22 (IL-22) Receptor Complex. THE IL-10R2 CHAIN (IL-10Rbeta ) IS a COMMON CHAIN OF BOTH THE IL-10 AND IL-22 (IL-10-RELATED T CELL-DERIVED INDUCIBLE FACTOR, IL-TIF) RECEPTOR COMPLEXES". Journal of Biological Chemistry. 276 (4): 2725–2732. doi:10.1074/jbc.M007837200. PMID 11035029.
- Chang, Y.; Al-Alwan, L.; Risse, P. -A.; Halayko, A. J.; Martin, J. G.; Baglole, C. J.; Eidelman, D. H.; Hamid, Q. (2012). "Th17-associated cytokines promote human airway smooth muscle cell proliferation". The FASEB Journal. 26 (12): 5152–5160. doi:10.1096/fj.12-208033. PMID 22898922.
- Shioya, M.; Andoh, A.; Kakinoki, S.; Nishida, A.; Fujiyama, Y. (2008). "Interleukin 22 Receptor 1 Expression in Pancreas Islets". Pancreas. 36 (2): 197–199. doi:10.1097/MPA.0b013e3181594258. PMID 18376313.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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