Oncostatin M receptor

OSMR
Identifiers
Aliases OSMR, OSMRB, PLCA1, IL-31R-beta, IL-31RB, oncostatin M receptor
External IDs OMIM: 601743 MGI: 1330819 HomoloGene: 2972 GeneCards: OSMR
Orthologs
Species Human Mouse
Entrez

9180

18414

Ensembl

ENSG00000145623

ENSMUSG00000022146

UniProt

Q99650

O70458

RefSeq (mRNA)

NM_011019
NM_001310469

RefSeq (protein)

NP_001297398.1
NP_035149.2

Location (UCSC) Chr 5: 38.85 – 38.95 Mb Chr 15: 6.81 – 6.87 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Oncostatin-M specific receptor subunit beta also known as the oncostatin M receptor, is one of the receptor proteins for oncostatin M, that in humans is encoded by the OSMR gene.[3][4]

OSMR is a member of the type I cytokine receptor family. This protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events.[3]

Clinical significance

The oncostatin M receptor is associated with primary cutaneous amyloidosis.[5]

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. 1 2 "Entrez Gene: oncostatin M receptor".
  4. ↑ Mosley B, De Imus C, Friend D, Boiani N, Thoma B, Park LS, Cosman D (December 1996). "Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation". J. Biol. Chem. 271 (51): 32635–43. doi:10.1074/jbc.271.51.32635. PMID 8999038.
  5. ↑ Arita K, South AP, Hans-Filho G, et al. (January 2008). "Oncostatin M Receptor-β Mutations Underlie Familial Primary Localized Cutaneous Amyloidosis". Am. J. Hum. Genet. 82 (1): 73–80. doi:10.1016/j.ajhg.2007.09.002. PMC 2253984Freely accessible. PMID 18179886.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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