Interleukin-36

Interleukin-36 also known as IL-36 is a cytokine that predominantly acts on naive CD4+ T cells via the IL-36 receptor. It is known to activate NF-κB and mitogen-activated protein kinases to play a role in skin pathology.[1] It has also been found to activate T cell proliferation and release of IL-2.[2]

In humans, there are three distinct genes, IL36A, IL36B, and IL36G.

References

  1. ↑ Towne JE, Renshaw BR, Douangpanya J, Lipsky BP, Shen M, Gabel CA, Sims JE (December 2011). "Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36α, IL-36β, and IL-36γ) or antagonist (IL-36Ra) activity". J. Biol. Chem. 286 (49): 42594–602. doi:10.1074/jbc.M111.267922. PMC 3234937Freely accessible. PMID 21965679.
  2. ↑ Vigne S, Palmer G, Martin P, Lamacchia C, Strebel D, Rodriguez E, Olleros ML, Vesin D, Garcia I, Ronchi F, Sallusto F, Sims JE, Gabay C (October 2012). "IL-36 signaling amplifies Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells". Blood. 120 (17): 3478–87. doi:10.1182/blood-2012-06-439026. PMID 22968459.


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