Interleukin 30

IL27
Identifiers
Aliases IL27, IL-27, IL-27A, IL27A, IL27p28, IL30, p28, Interleukin 30, IL-30, interleukin 27
External IDs MGI: 2384409 HomoloGene: 17087 GeneCards: IL27
Orthologs
Species Human Mouse
Entrez

246778

246779

Ensembl

ENSG00000197272

ENSMUSG00000044701

UniProt

Q8NEV9

Q8K3I6

RefSeq (mRNA)

NM_145659

NM_145636

RefSeq (protein)

NP_663634.2

NP_663611.1

Location (UCSC) Chr 16: 28.5 – 28.51 Mb Chr 7: 126.59 – 126.59 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Interleukin-30 (IL-30) is a protein with a molecular weight of 28 kilodaltons, which forms one chain of the heterodimeric cytokine called interleukin 27 (IL-27), thus is sometimes called IL27-p28. The other chain of IL-27 is a molecule called Epstein-Barr induced gene-3 (EBI3). IL-30 is a member of the long-chain, 4-helix bundle family of cytokines, making it structurally similar to IL-6.[3] This gene for this molecule is now officially called IL-27 under HGNC guidelines.[4]

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. ↑ Pflanz S, Timans JC, Cheung J, Rosales R, Kanzler H, Gilbert J, Hibbert L, Churakova T, Travis M, Vaisberg E, Blumenschein WM, Mattson JD, Wagner JL, To W, Zurawski S, McClanahan TK, Gorman DM, Bazan JF, de Waal Malefyt R, Rennick D, Kastelein RA (June 2002). "IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells". Immunity. 16 (6): 779–90. doi:10.1016/S1074-7613(02)00324-2. PMID 12121660.
  4. ↑ http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=19157



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