Cholecystokinin receptor

cholecystokinin A receptor
Identifiers
Symbol CCKAR
Entrez 886
HUGO 1570
OMIM 118444
RefSeq NM_000730
UniProt P32238
Other data
Locus Chr. 4 p15.2-p15.1
cholecystokinin B receptor
Identifiers
Symbol CCKBR
Entrez 887
HUGO 1571
OMIM 118445
RefSeq NM_176875
UniProt P32239
Other data
Locus Chr. 11 p15.4

Cholecystokinin receptors or CCK receptors are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) and gastrin.[1] There are two different subtypes CCKA and CCKB which are ~50% homologous:[2] Various cholecystokinin antagonists have been developed and are used in research, although the only drug of this class that has been widely marketed to date is the anti-ulcer drug proglumide.

protein gene tissue distribution preferred ligand function
CCKA (CCK1) CCKAR primarily gastrointestinal tract, lesser amounts in the CNS sulfated CCK >> nonsulfated CCK ≈ nonsulfated CCK stimulation of bicarb secretion, gall bladder emptying and inhibiting gut motility
CCKB (CCK2) CCKBR primarily CNS, lesser amounts in the gastrointestinal tract gastrin ≈ CCK (receptor does not discriminate between sulfated and nonsulfated peptides) regulation of nociception, anxiety, memory and hunger

References

  1. ↑ Noble F, Wank SA, Crawley JN, Bradwejn J, Seroogy KB, Hamon M, Roques BP (December 1999). "International Union of Pharmacology. XXI. Structure, distribution, and functions of cholecystokinin receptors". Pharmacological Reviews. 51 (4): 745–81. PMID 10581329.
  2. ↑ Dufresne M, Seva C, Fourmy D (2006). "Cholecystokinin and gastrin receptors". Physiol. Rev. 86 (3): 805–47. doi:10.1152/physrev.00014.2005. PMID 16816139.

External links


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