Galmic
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| Identifiers | |
|---|---|
| PubChem (CID) | 11636593 |
| ChemSpider |
25046661  |
| ChEMBL |
CHEMBL578918 |
| Chemical and physical data | |
| Formula | C51H60N10O11 |
| Molar mass | 989.080 |
| 3D model (Jmol) | Interactive image |
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 (what is this?) (verify) | |
Galmic is a drug which acts as a selective, non-peptide agonist at the galanin receptors GALR.[1] It has anticonvulsant, antidepressant and analgesic effects in animal studies,[2] but also inhibits memory functions.[3]
References
- ↑ Ceide SC, Trembleau L, Haberhauer G, Somogyi L, Lu X, Bartfai T, Rebek J (November 2004). "Synthesis of galmic: a nonpeptide galanin receptor agonist". Proceedings of the National Academy of Sciences of the United States of America. 101 (48): 16727–32. doi:10.1073/pnas.0407543101. PMC 534730
. PMID 15557002. - ↑ Bartfai T, Lu X, Badie-Mahdavi H, Barr AM, Mazarati A, Hua XY, Yaksh T, Haberhauer G, Ceide SC, Trembleau L, Somogyi L, Kröck L, Rebek J (July 2004). "Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests". Proceedings of the National Academy of Sciences of the United States of America. 101 (28): 10470–5. doi:10.1073/pnas.0403802101. PMC 478593. PMID 15240875.
- ↑ Badie-Mahdavi H, Behrens MM, Rebek J, Bartfai T (June 2005). "Effect of galnon on induction of long-term potentiation in dentate gyrus of C57BL/6 mice". Neuropeptides. 39 (3): 249–51. doi:10.1016/j.npep.2004.12.010. PMID 15944018.
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