MRGPRD

Identifiers

MRGPRD, MRGD, TGR7, MAS related GPR family member D

External IDs

MGI: 3033142 HomoloGene: 18893 GeneCards: MRGPRD

Targeted by Drug

Gene ontology
Molecular function	• G-protein coupled receptor activity • signal transducer activity
Cellular component	• extracellular fluid • integral component of membrane • plasma membrane • integral component of plasma membrane • membrane
Biological process	• G-protein coupled receptor signaling pathway • signal transduction
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


116512


211578

Ensembl


ENSG00000172938


ENSMUSG00000051207

UniProt


Q8TDS7


Q91ZB8

RefSeq (mRNA)


NM_198923


NM_203490

RefSeq (protein)


NP_944605.2


NP_987075.1

Location (UCSC)

Chr 11: 68.98 – 68.98 Mb

Chr 7: 145.31 – 145.32 Mb

PubMed search

^[2]

^[3]

Wikidata

View/Edit Human

View/Edit Mouse

Mas-related G-protein coupled receptor member D is a protein that in humans is encoded by the MRGPRD gene.^[4]^[5]^[6]

References

↑ "Drugs that physically interact with Mas-related G-protein coupled receptor member D view/edit references on wikidata".
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Dong X, Han S, Zylka MJ, Simon MI, Anderson DJ (Sep 2001). "A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons". Cell. 106 (5): 619–32. doi:10.1016/S0092-8674(01)00483-4. PMID 11551509.
↑ Zylka MJ, Dong X, Southwell AL, Anderson DJ (Aug 2003). "Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family". Proc Natl Acad Sci U S A. 100 (17): 10043–8. doi:10.1073/pnas.1732949100. PMC 187757. PMID 12909716.
↑ "Entrez Gene: MRGPRD MAS-related GPR, member D".

Takeda S, Kadowaki S, Haga T, et al. (2002). "Identification of G protein-coupled receptor genes from the human genome sequence.". FEBS Lett. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878.
Shinohara T, Harada M, Ogi K, et al. (2004). "Identification of a G protein-coupled receptor specifically responsive to beta-alanine". J. Biol. Chem. 279 (22): 23559–64. doi:10.1074/jbc.M314240200. PMID 15037633.

Cell surface receptor: G protein-coupled receptors

Class A: Rhodopsin like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3

Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)

Serotonin	(all but 5-HT3) 5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)

Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine (D1 D2 D3 D4 D5) Histamine (H1 H2 H3 H4) Melatonin (1A 1B 1C) TAAR (1 2 3 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 (1 2) FPRL1 OXE Prostaglandin (DP (1 2), EP (1 2 3 4), FP) Prostacyclin Thromboxane

Other	Bile acid Cannabinoid (CB1 CB2, GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Lactate Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Niacin (1 2) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Neuropeptide	B/W (1 2) FF (1 2) S Y (1 2 4 5) Neuromedin (B U (1 2)) Neurotensin (1 2)

Other	Anaphylatoxin (C3a C5a) Angiotensin (1 2) Apelin Bombesin (BRS3 GRPR NMBR) Bradykinin (B1 B2) Chemokine Cholecystokinin (A B) Endothelin (A B) Formyl peptide (1 2 3) FSH Galanin (1 2 3) GHB receptor Gonadotropin-releasing hormone (1 2) Ghrelin Kisspeptin Luteinizing hormone/choriogonadotropin MAS (1 1L D E F G X1 X2 X3 X4) Melanocortin (1 2 3 4 5) MCHR (1 2) Motilin Opioid (Delta Kappa Mu Nociceptin & Zeta, but not Sigma) Orexin (1 2) Oxytocin Prokineticin (1 2) Prolactin-releasing peptide Relaxin (1 2 3 4) Somatostatin (1 2 3 4 5) Tachykinin (1 2 3) Thyrotropin Thyrotropin-releasing hormone Urotensin-II Vasopressin (1A 1B 2)

Miscellaneous

Orphan	GPR (1 3 4 6 12 15 17 18 19 20 21 22 23 25 26 27 31 32 33 34 35 37 39 42 44 45 50 52 55 61 62 63 65 68 75 77 78 81 82 83 84 85 87 88 92 101 103 109A 109B 119 120 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)

Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B: Secretin like

Adhesion	ADGRG (1 2 3 4 5 6 7)

Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)

Other	Brain-specific angiogenesis inhibitor (1 2 3) Cadherin (1 2 3) Calcitonin CALCRL CD97 Corticotropin-releasing hormone (1 2) EMR (1 2 3) Glucagon (GR GIPR GLP1R GLP2R) Growth hormone releasing hormone PACAPR1 GPR Latrophilin (1 2 3 ELTD1) Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C: Metabotropic glutamate / pheromone

Taste	TAS1R (1 2 3) TAS2R (1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor)

Other	Calcium-sensing receptor GABA B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)

Class F: Frizzled / Smoothened

Frizzled	Frizzled (1 2 3 4 5 6 7 8 9 10)

Smoothened	Smoothened

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MRGPRD

See also

References

Further reading