Quinapril

Quinapril
Clinical data
Trade names Accupril
AHFS/Drugs.com Monograph
MedlinePlus a692026
Pregnancy
category
  • D
Routes of
administration
Oral
ATC code C09AA06 (WHO)
Legal status
Legal status
  • ℞ (Prescription only)
Pharmacokinetic data
Protein binding 97%
Biological half-life 2 hours
Identifiers
CAS Number 85441-61-8 YesY
PubChem (CID) 54892
IUPHAR/BPS 6350
DrugBank DB00881 YesY
ChemSpider 49565 YesY
UNII RJ84Y44811 YesY
KEGG D03752 YesY
ChEBI CHEBI:8713 YesY
ChEMBL CHEMBL1592 YesY
Chemical and physical data
Formula C25H30N2O5
Molar mass 438.516 g/mol
3D model (Jmol) Interactive image
Melting point 120 to 130 °C (248 to 266 °F)
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Quinapril (marketed under the brand name Accupril by Pfizer) is an angiotensin-converting enzyme inhibitor (ACE inhibitor) used in the treatment of hypertension and congestive heart failure. A prodrug, it is converted to its active metabolite, quinaprilat, in the liver.

Mechanism of action

Main article: ACE inhibitor

Quinapril inhibits angiotensin converting enzyme, an enzyme which catalyses the formation of angiotensin II from its precursor, angiotensin I. Angiotensin II is a powerful vasoconstrictor and increases blood pressure through a variety of mechanisms. Due to reduced angiotensin production, plasma concentrations of aldosterone are also reduced, resulting in increased excretion of sodium in the urine and increased concentrations of potassium in the blood.

Indications

Quinapril is indicated for the treatment of high blood pressure (hypertension) and as adjunctive therapy in the management of heart failure. It may be used for the treatment of hypertension by itself or in combination with thiazide diuretics, and with diuretics and digoxin for heart failure.

Contraindications

Side effects

Side effects of quinapril include dizziness, cough, vomiting, upset stomach, angioedema, and fatigue.

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