LASSBio-881
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| Identifiers | |
|---|---|
| PubChem (CID) | 16721055 |
| ChemSpider | 23293401 |
| ChEMBL | CHEMBL234619 |
| Chemical and physical data | |
| Formula | C23H27N3O6 |
| Molar mass | 441.476 g/mol |
| 3D model (Jmol) | Interactive image |
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LASSBio-881 is a drug which acts as both a non-selective partial agonist of the CB1 and CB2 cannabinoid receptors, and also as an antagonist of the TRPV1 receptor, as well as having antioxidant effects. It has potent anti-inflammatory and anti-hyperalgesic effects in animal studies.[1][2][3]
References
- ↑ Duarte CD, Tributino JL, Lacerda DI, Martins MV, Alexandre-Moreira MS, Dutra F, Bechara EJ, De-Paula FS, Goulart MO, Ferreira J, Calixto JB, Nunes MP, Bertho AL, Miranda AL, Barreiro EJ, Fraga CA. Synthesis, pharmacological evaluation and electrochemical studies of novel 6-nitro-3,4-methylenedioxyphenyl-N-acylhydrazone derivatives: Discovery of LASSBio-881, a new ligand of cannabinoid receptors. Bioorganic and Medicinal Chemistry. 2007 Mar 15;15(6):2421-33. PMID 17275312
- ↑ Tributino JL, Santos ML, Mesquita CM, Lima CK, Silva LL, Maia RC, Duarte CD, Barreiro EJ, Fraga CA, Castro NG, Miranda AL, Guimaraes MZ. LASSBio-881: an N-acylhydrazone transient receptor potential vanilloid subfamily type 1 antagonist orally effective against the hypernociception induced by capsaicin or partial sciatic ligation. British Journal of Pharmacology. 2010 Apr;159(8):1716-23. PMID 20401963
- ↑ Santana P et al. NEUROACTIVE PROPERTIES OF THE MULTIFUNCTIONAL PROTOTYPE LASSBio-881: FOCUS ON THE CANNABINOID SYSTEM
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