4'-Fluorocannabidiol
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| CAS Number | 1619228-89-5 |
| PubChem (CID) | 76285390 |
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| Formula | C21H29FO2 |
| Molar mass | 332.46 g·mol−1 |
| 3D model (Jmol) | Interactive image |
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4'-Fluorocannabidiol (also known as HUF-101 and 4'-F-CBD) is a fluorinated cannabidiol derivative that has more potent anxiolytic, antidepressant, antipsychotic and anti-compulsive activity in mice compared to its parent compound.[1] It was first synthesized in 2016, alongside 10-Fluorocannabidiol diacetate and 8,9-Dihydro-7-fluorocannabidiol.[1]
Synthesis
4'-fluoro-cannabidiol was synthesized from isolated cannabidiol by putting it in dry dichloromethane and adding 1-fluoropyridinium triflate.[1]
See also
- 2-Isopropyl-5-methyl-1-(2,6-dihydroxy-4-nonylphenyl)cyclohex-1-ene
- Abnormal cannabidiol
- Cannabinodiol
- Cannabinoids
- Cannabinoid receptors
- HU-331
- O-1602
- O-1918
References
- 1 2 3 Breuer, Aviva; Haj, Christeene G.; Fogaça, Manoela V.; Gomes, Felipe V.; Silva, Nicole Rodrigues; Pedrazzi, João Francisco; Bel, Elaine A. Del; Hallak, Jaime C.; Crippa, José A.; Zuardi, Antonio W.; Mechoulam, Raphael; Guimarães, Francisco S. (14 July 2016). "Fluorinated Cannabidiol Derivatives: Enhancement of Activity in Mice Models Predictive of Anxiolytic, Antidepressant and Antipsychotic Effects". PLOS ONE. 11 (7): e0158779. ISSN 1932-6203. PMC 4945002
. PMID 27416026.
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