AM-087

AM-087

Identifiers
IUPAC name (6aR,10aR)-3-(2-methyl-6-bromohex-2-yl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol
CAS Number	152674-96-9 Y
PubChem (CID)	10717065
ChemSpider	8892405 Y
ChEMBL	CHEMBL199561 Y
Chemical and physical data
Formula	C23H33BrO2
Molar mass	421.410 g/mol
3D model (Jmol)	Interactive image
SMILES CC3(C)C1CC=C(C)CC1c2c(O)cc(C(C)(C)CCCCBr)cc2O3
InChI InChI=1S/C23H33BrO2/c1-15-8-9-18-17(12-15)21-19(25)13-16(14-20(21)26-23(18,4)5)22(2,3)10-6-7-11-24/h8,13-14,17-18,25H,6-7,9-12H2,1-5H3/t17-,18-/m1/s1 Y Key:RJPGJHLVEUSRRA-QZTJIDSGSA-N Y
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AM-087 (part of the AM cannabinoid series) is an analgesic drug which acts as a cannabinoid agonist.^[1] It is a derivative of Δ8THC substituted on the 3-position side chain. AM-087 is a potent CB₁ agonist with a Ki of 0.43nM, making it around 100x more potent than THC itself. This is most likely due to the bulky bromine substituent on the side chain.^[2]

See also

• AM-411

References

1. ↑ Martin, Billy R.; Compton, David R.; Semus, Simon F.; Lin, Sonyuan; Marciniak, Gilbert; Grzybowska, Jolanta; Charalambous, Avgui; Makriyannis, Alexandros (1993). "Pharmacological evaluation of iodo and nitro analogs of Δ8-THC and Δ9-THC". Pharmacology Biochemistry and Behavior. 46 (2): 295–301. doi:10.1016/0091-3057(93)90356-X. ISSN 0091-3057. 
2. ↑ Charalambous A, et al. Pharmacological evaluation of halogenated delta 8-THC analogs. Pharmacology, Biochemistry and Behaviour. 1991 Nov;40(3):509-12. PMID 1666915