HU-336
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| Identifiers | |
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| PubChem (CID) | 11370880 |
| ChemSpider |
9545797  |
| Chemical and physical data | |
| Formula | C21H28O3 |
| Molar mass | 328.445 g/mol |
| 3D model (Jmol) | Interactive image |
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| (verify) | |
HU-336 is a strongly antiangiogenic compound, significantly inhibiting angiogenesis at concentrations as low as 300 nM. It inhibits angiogenesis by directly inducing apoptosis of vascular endothelial cells without changing the expression of pro- and antiangiogenic cytokines and their receptors. HU-336 is highly effective against tumor xenografts in nude mice.[1]
See also
References
- ↑ Natalya M. Kogan; et al. (2006). "A Cannabinoid Quinone Inhibits Angiogenesis by Targeting Vascular Endothelial Cells". Molecular Pharmacology. 70 (1): 51–59. doi:10.1124/mol.105.021089. PMID 16571653.
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