TRPM5
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Transient receptor potential cation channel subfamily M member 5 (TRPM5), also known as long transient receptor potential channel 5 is a protein that in humans is encoded by the TRPM5 gene.[4][5]
Function
TRPM5 is a key component of taste transduction in the gustatory system of bitter, sweet and umami tastes being activated by high levels of intracellular calcium. It has also been targeted as a possible contributor to fat taste signaling.[6][7] The calcium dependent opening of TRPM5 produces a depolarizing generator potential which leads to an action potential.[8]
See also
References
- ↑ "Drugs that physically interact with Transient receptor potential cation channel subfamily M member 5 view/edit references on wikidata".
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Prawitt D, Enklaar T, Klemm G, Gärtner B, Spangenberg C, Winterpacht A, Higgins M, Pelletier J, Zabel B (January 2000). "Identification and characterization of MTR1, a novel gene with homology to melastatin (MLSN1) and the trp gene family located in the BWS-WT2 critical region on chromosome 11p15.5 and showing allele-specific expression". Hum. Mol. Genet. 9 (2): 203–16. doi:10.1093/hmg/9.2.203. PMID 10607831.
- ↑ Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100.
- ↑ PMID 21557960
- ↑ PMID 21653867
- ↑ Chaudhari N, Roper SD (August 2010). "The cell biology of taste". J. Cell Biol. 190 (3): 285–96. doi:10.1083/jcb.201003144. PMC 2922655
. PMID 20696704.
Further reading
- Islam, Md. Shahidul (January 2011). Transient Receptor Potential Channels. Advances in Experimental Medicine and Biology. 704. Berlin: Springer. p. 700. ISBN 978-94-007-0264-6.
- Liman ER (2007). "TRPM5 and taste transduction". Handb Exp Pharmacol. Handbook of Experimental Pharmacology. 179 (179): 287–98. doi:10.1007/978-3-540-34891-7_17. ISBN 978-3-540-34889-4. PMID 17217064.
- Holzer P (July 2011). "Transient receptor potential (TRP) channels as drug targets for diseases of the digestive system". Pharmacology and Therapeutics. 131 (1): 142–170. doi:10.1016/j.pharmthera.2011.03.006. PMC 3107431. PMID 21420431.
- Boesmans W, Owsianik G, Tack J, Voets T, Vanden Berghe P (January 2011). "TRP channels in neurogastroenterology: opportunities for therapeutic intervention". British Journal of Pharmacology. 162 (1): 18–37. doi:10.1111/j.1476-5381.2010.01009.x. PMC 3012403. PMID 20804496.
- Emily R Liman (2010). "Changing Taste by Targeting the Ion Channel TRPM5". The Open Drug Discovery Journal. 2: 98–102.
- Brixel LR, Monteilh-Zoller MK, Ingenbrandt CS, Fleig A, Penner R, Enklaar T, Zabel BU, Prawitt D (June 2010). "TRPM5 regulates glucose-stimulated insulin secretion". Pflugers Archive - European Journal of Physiology. 460 (1): 69–76. doi:10.1007/s00424-010-0835-z. PMID 20393858.
- Oliveira-Maia AJ, Stapleton-Kotloski JR, Lyall V, Phan TH, Mummalaneni S, Melone P, Desimone JA, Nicolelis MA, Simon SA (February 2009). "Nicotine activates TRPM5-dependent and independent taste pathways". Proceedings of the National Academy of Sciences of the United States of America. 106 (5): 1596–1601. doi:10.1073/pnas.0810184106. PMC 2635785. PMID 19164511.
- Dan Liu; Zheng Zhang & Emily R. Liman (May 2005). "Extracellular Acid Block and Acid-enhanced Inactivation of the Ca2+-activated Cation Channel TRPM5 Involve Residues in the S3-S4 and S5-S6 Extracellular Domains". The Journal of Biological Chemistry. 280 (21): 20691–20699. doi:10.1074/jbc.M414072200. PMID 15731110.
- Liu D, Liman ER (December 2003). "Intracellular Ca2+ and the phospholipid PIP2 regulate the taste transduction ion channel TRPM5". Proceedings of the National Academy of Sciences of the United States of America. 100 (25): 15160–15165. doi:10.1073/pnas.2334159100. PMC 299934. PMID 14657398.
- Wu LJ, Sweet TB, Clapham DE (September 2010). "International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family". Pharmacological Reviews. 62 (3): 381–404. doi:10.1124/pr.110.002725. PMC 2964900. PMID 20716668.
External links
- TRPM5 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
- IUPHAR
- HGNC Gene families
- Pfam
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