CACNA1G

Identifiers

Aliases

CACNA1G, Ca(V)T.1, Cav3.1, NBR13, SCA42, calcium voltage-gated channel subunit alpha1 G

External IDs

MGI: 1201678 HomoloGene: 22544 GeneCards: CACNA1G

Genetically Related Diseases

Alzheimer's disease^[1]

Targeted by Drug

anandamide, mibefradil^[2]

Gene ontology
Molecular function	• voltage-gated calcium channel activity • calcium channel activity • scaffold protein binding • voltage-gated ion channel activity • ion channel activity • voltage-gated calcium channel activity involved in AV node cell action potential • voltage-gated calcium channel activity involved SA node cell action potential • low voltage-gated calcium channel activity
Cellular component	• integral component of membrane • membrane • voltage-gated calcium channel complex • cytoplasm • plasma membrane
Biological process	• membrane depolarization during action potential • calcium ion import • regulation of membrane potential • regulation of ion transmembrane transport • regulation of atrial cardiac muscle cell membrane depolarization • ion transport • regulation of heart rate • positive regulation of calcium ion-dependent exocytosis • transmembrane transport • action potential • response to nickel cation • calcium ion transport • chemical synaptic transmission • AV node cell to bundle of His cell signaling • regulation of heart rate by cardiac conduction • SA node cell action potential • AV node cell action potential • SA node cell to atrial cardiac muscle cell signalling • membrane depolarization during AV node cell action potential • transport • calcium ion transmembrane transport • membrane depolarization during SA node cell action potential
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


8913


12291

Ensembl


ENSG00000006283


ENSMUSG00000020866

UniProt


O43497


n/a

RefSeq (mRNA)

NM_001256324 NM_001256325 NM_001256326 NM_001256327 NM_001256328
NM_001256329 NM_001256330 NM_001256331 NM_001256332 NM_001256333 NM_001256334 NM_001256359 NM_001256360 NM_001256361 NM_018896 NM_198376 NM_198377 NM_198378 NM_198379 NM_198380 NM_198382 NM_198383 NM_198384 NM_198385 NM_198386 NM_198387 NM_198388 NM_198396 NM_198397


NM_001112813 NM_001177888 NM_001177890 NM_009783

RefSeq (protein)

NP_001243253.1 NP_001243254.1 NP_001243255.1 NP_001243256.1 NP_001243257.1
NP_001243258.1 NP_001243259.1 NP_001243260.1 NP_001243261.1 NP_001243262.1 NP_001243263.1 NP_001243288.1 NP_001243289.1 NP_001243290.1 NP_061496.2 NP_938190.1 NP_938191.2 NP_938192.1 NP_938193.1 NP_938194.1 NP_938196.1 NP_938197.1 NP_938198.1 NP_938199.1 NP_938200.1 NP_938201.1 NP_938202.1 NP_938406.1


n/a

Location (UCSC)

Chr 17: 50.56 – 50.63 Mb

Chr 11: 94.41 – 94.47 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Calcium channel, voltage-dependent, T type, alpha 1G subunit, also known as CACNA1G or Ca_v3.1 is a protein which in humans is encoded by the CACNA1G gene.^[5]^[6]^[7]

Function

Voltage-dependent calcium channels can be distinguished based on their voltage-dependence, deactivation, and single-channel conductance. Low-voltage-activated calcium channels are referred to as 'T' type because their currents are both transient, owing to fast inactivation, and tiny, owing to small conductance. T-type channels are thought to be involved in pacemaker activity, low-threshold calcium spikes, neuronal oscillations and resonance, and rebound burst firing.^[5]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective Wikipedia articles. ^{[§ 1]}

[[File:

NicotineActivityonChromaffinCells_WP1603

[[<div style="display:block; width:38px; height:0px; overflow:hidden; position:relative; left:396.0px; top:221px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:63px; height:0px; overflow:hidden; position:relative; left:307.0px; top:124px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:32px; height:0px; overflow:hidden; position:relative; left:67.5px; top:295px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:32px; height:0px; overflow:hidden; position:relative; left:168.0px; top:259px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:38px; height:0px; overflow:hidden; position:relative; left:396.0px; top:62px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:80px; height:0px; overflow:hidden; position:relative; left:375.0px; top:356px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:61px; height:0px; overflow:hidden; position:relative; left:107.0px; top:228px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:61px; height:0px; overflow:hidden; position:relative; left:107.0px; top:208px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:33px; height:0px; overflow:hidden; position:relative; left:67.0px; top:259px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:57px; height:0px; overflow:hidden; position:relative; left:25.0px; top:177px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:63px; height:0px; overflow:hidden; position:relative; left:307.0px; top:144px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:32px; height:0px; overflow:hidden; position:relative; left:168.0px; top:295px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:80px; height:0px; overflow:hidden; position:relative; left:591.0px; top:356px; background:transparent; border-top:3px blue solid"></div>]]

[[

]]

|{{{bSize}}}px|alt=Nicotine Activity on Chromaffin Cells edit]]

Nicotine Activity on Chromaffin Cells edit

↑ The interactive pathway map can be edited at WikiPathways: "NicotineActivityonChromaffinCells_WP1603".

References

↑ "Diseases that are genetically associated with CACNA1G view/edit references on wikidata".
↑ "Drugs that physically interact with Voltage-dependent T-type calcium channel subunit alpha-1G view/edit references on wikidata".
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
1 2 "Entrez Gene: CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit".
↑ Perez-Reyes E, Cribbs LL, Daud A, Lacerda AE, Barclay J, Williamson MP, Fox M, Rees M, Lee JH (February 1998). "Molecular characterization of a neuronal low-voltage-activated T-type calcium channel". Nature. 391 (6670): 896–900. doi:10.1038/36110. PMID 9495342.
↑ Catterall WA, Perez-Reyes E, Snutch TP, Striessnig J (December 2005). "International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels". Pharmacol. Rev. 57 (4): 411–25. doi:10.1124/pr.57.4.5. PMID 16382099.

External links

CACNA1G protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3

Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ

Proton-gated	Amiloride-sensitive cation channel 1 2 3 4

Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1

Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1

Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18

Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker gene

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B

H⁺: Proton channel	HVCN1

M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4

M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6

H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family

Cytoplasm: Gap junction	Connexin: A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4) Innexin

By gating mechanism

Ion channel class	Ligand-gated Light-gated Voltage-gated Stretch-activated

see also disorders

This article is issued from Wikipedia - version of the 5/21/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.

CACNA1G

Function

Interactive pathway map

See also

References

External links