PRKCG

PRKCG
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E73, 2UZP
Identifiers
Aliases	PRKCG, PKC-gamma, PKCC, PKCG, SCA14, protein kinase C gamma
External IDs	MGI: 97597 HomoloGene: 20602 GeneCards: PRKCG
Targeted by Drug
ingenol mebutate, balanol, enzastaurin, ruboxistaurin[1]
Gene ontology Molecular function • transferase activity • protein kinase activity • nucleotide binding • protein kinase C activity • zinc ion binding • metal ion binding • kinase activity • protein serine/threonine kinase activity • protein serine/threonine/tyrosine kinase activity • ATP binding • calcium-dependent protein kinase C activity Cellular component • cytoplasm • synaptic membrane • cytosol • cell projection • membrane • cell-cell junction • plasma membrane • synapse • intracellular • cell junction • dendrite • perinuclear region of cytoplasm • neuron projection • nucleus Biological process • negative regulation of neuron apoptotic process • intracellular signal transduction • phosphorylation • negative regulation of protein catabolic process • rhythmic process • regulation of response to food • response to stress • platelet activation • chemosensory behavior • negative regulation of protein ubiquitination • protein phosphorylation • response to morphine • positive regulation of mismatch repair • response to pain • regulation of circadian rhythm • peptidyl-serine phosphorylation • learning or memory • protein autophosphorylation • negative regulation of proteasomal protein catabolic process • regulation of phagocytosis • innervation • chemical synaptic transmission Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5582	18752
Ensembl	ENSG00000126583	n/a
UniProt	P05129	P63318
RefSeq (mRNA)	NM_002739 NM_001316329	NM_001291434 NM_011102
RefSeq (protein)	NP_002730.1 NP_001303258.1	NP_035232.1
Location (UCSC)	Chr 19: 53.88 – 53.91 Mb	Chr 7: 3.29 – 3.33 Mb
PubMed search	[2]	[3]
Wikidata

Protein kinase C gamma type is an enzyme that in humans is encoded by the PRKCG gene.^[4][5]

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14).^[6]

Interactions

PRKCG has been shown to interact with GRIA4.^[7]

See also

• Protein kinase C

References

External links

• GeneReviews/NCBI/NIH/UW entry on Spinocerebellar Ataxia Type 14

Further reading

PDB gallery
1tbn: NMR STRUCTURE OF A PROTEIN KINASE C-G PHORBOL-BINDING DOMAIN, MINIMIZED AVERAGE STRUCTURE  1tbo: NMR STRUCTURE OF A PROTEIN KINASE C-G PHORBOL-BINDING DOMAIN, 30 STRUCTURES  2uzp: CRYSTAL STRUCTURE OF THE C2 DOMAIN OF HUMAN PROTEIN KINASE C GAMMA.