MAP2K6

MAP2K6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2Y8O, 3ENM, 3FME, 3VN9
Identifiers
Aliases	MAP2K6, MAPKK6, MEK6, MKK6, PRKMK6, SAPKK-3, SAPKK3, mitogen-activated protein kinase kinase 6
External IDs	MGI: 1346870 HomoloGene: 55686 GeneCards: MAP2K6
Targeted by Drug
staurosporine[1]
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • kinase activity • protein binding • protein tyrosine kinase activity • ATP binding • protein kinase binding • MAP kinase kinase activity • protein serine/threonine kinase activity • signal transducer, downstream of receptor, with serine/threonine kinase activity Cellular component • cytoplasm • cytosol • nucleoplasm • cytoskeleton • nucleus Biological process • positive regulation of protein phosphorylation • regulation of transcription, DNA-templated • cardiac muscle contraction • phosphorylation • cellular response to sorbitol • positive regulation of nitric-oxide synthase biosynthetic process • ovulation cycle process • transcription, DNA-templated • MAPK cascade • protein phosphorylation • positive regulation of prostaglandin secretion • response to ischemia • activation of MAPK activity • cell cycle arrest • DNA damage induced protein phosphorylation • positive regulation of apoptotic process • peptidyl-tyrosine phosphorylation • nucleotide-binding oligomerization domain containing signaling pathway • response to drug • signal transduction • apoptotic process • proteolysis in other organism Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5608	26399
Ensembl	ENSG00000108984	ENSMUSG00000020623
UniProt	P52564	P70236
RefSeq (mRNA)	NM_002758 NM_031988	NM_011943
RefSeq (protein)	NP_002749.2	NP_036073.1
Location (UCSC)	Chr 17: 69.41 – 69.54 Mb	Chr 11: 110.4 – 110.53 Mb
PubMed search	[2]	[3]
Wikidata

Dual specificity mitogen-activated protein kinase kinase 6 also known as MAP kinase kinase 6 (MAPKK 6) or MAPK/ERK kinase 6 is an enzyme that in humans is encoded by the MAP2K6 gene, on chromosome 17.^[4]

Function

MAPKK 6 is a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress-induced cell cycle arrest, transcription activation and apoptosis.^[5]

Interactions

MAP2K6 has been shown to interact with TAOK2,^[6] ASK1,^[7][8] MAPK14^{[6][9][10][11]} and MAP3K7.^{[12][13][14][15]}

References

Further reading