PRKACB

PRKACB
Identifiers
Aliases	PRKACB, PKA C-beta, PKACB, protein kinase cAMP-activated catalytic subunit beta
External IDs	MGI: 97594 HomoloGene: 121718 GeneCards: PRKACB
Targeted by Drug
staurosporine[1]
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • cAMP-dependent protein kinase activity • protein binding • ATP binding • ubiquitin protein ligase binding • magnesium ion binding • kinase activity • protein serine/threonine kinase activity Cellular component • cytoplasm • cytosol • centrosome • membrane • plasma membrane • nucleoplasm • ciliary base • perinuclear region of cytoplasm • cAMP-dependent protein kinase complex • extracellular exosome • nucleus Biological process • negative regulation of meiotic cell cycle • activation of protein kinase A activity • phosphorylation • adenylate cyclase-modulating G-protein coupled receptor signaling pathway • cellular response to glucagon stimulus • negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning • blood coagulation • stimulatory C-type lectin receptor signaling pathway • regulation of protein processing • protein phosphorylation • neural tube closure • response to clozapine • renal water homeostasis • signal transduction • lipoprotein metabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5567	18749
Ensembl	ENSG00000142875	ENSMUSG00000005034
UniProt	P22694	P68181
RefSeq (mRNA)	NM_001242857 NM_001242858 NM_001242859 NM_001242860 NM_001242861 NM_001242862 NM_001300915 NM_001300916 NM_001300917 NM_002731 NM_182948 NM_207578	NM_001164198 NM_001164199 NM_001164200 NM_011100
RefSeq (protein)	NP_001229786.1 NP_001229787.1 NP_001229788.1 NP_001229789.1 NP_001229790.1 NP_001229791.1 NP_001287844.1 NP_001287845.1 NP_001287846.1 NP_002722.1 NP_891993.1 NP_997461.1 NP_002722.1	NP_001157670.1 NP_001157671.1 NP_001157672.1 NP_035230.1
Location (UCSC)	Chr 1: 84.08 – 84.24 Mb	Chr 3: 146.73 – 146.81 Mb
PubMed search	[2]	[3]
Wikidata

cAMP-dependent protein kinase catalytic subunit beta is an enzyme that in humans is encoded by the PRKACB gene.^[4]

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the protein kinase A (PKA), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of PKA is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of PKA have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of PKA. Three alternatively spliced transcript variants encoding distinct isoforms have been observed.^[4]

Interactions

PRKACB has been shown to interact with Ryanodine receptor 2^[5] and Low affinity nerve growth factor receptor.^[6]

References

Further reading

PDB gallery
1apm: 2.0 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH A PEPTIDE INHIBITOR AND DETERGENT  1atp: 2.2 angstrom refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MNATP and a peptide inhibitor  1bkx: A BINARY COMPLEX OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE AND ADENOSINE FURTHER DEFINES CONFORMATIONAL FLEXIBILITY  1bx6: CRYSTAL STRUCTURE OF THE POTENT NATURAL PRODUCT INHIBITOR BALANOL IN COMPLEX WITH THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE  1cdk: CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT (E.C.2.7.1.37) (PROTEIN KINASE A) COMPLEXED WITH PROTEIN KINASE INHIBITOR PEPTIDE FRAGMENT 5-24 (PKI(5-24) ISOELECTRIC VARIANT CA) AND MN2+ ADENYLYL IMIDODIPHOSPHATE (MNAMP-PNP) AT PH 5.6 AND 7C AND 4C  1cmk: CRYSTAL STRUCTURES OF THE MYRISTYLATED CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE REVEAL OPEN AND CLOSED CONFORMATIONS  1ctp: STRUCTURE OF THE MAMMALIAN CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE AND AN INHIBITOR PEPTIDE DISPLAYS AN OPEN CONFORMATION  1fmo: CRYSTAL STRUCTURE OF A POLYHISTIDINE-TAGGED RECOMBINANT CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH THE PEPTIDE INHIBITOR PKI(5-24) AND ADENOSINE  1j3h: Crystal structure of apoenzyme cAMP-dependent protein kinase catalytic subunit  1jbp: Crystal Structure of the Catalytic Subunit of cAMP-dependent Protein Kinase Complexed with a Substrate Peptide, ADP and Detergent  1jlu: Crystal Structure of the Catalytic Subunit of cAMP-dependent Protein Kinase Complexed with a Phosphorylated Substrate Peptide and Detergent  1l3r: Crystal Structure of a Transition State Mimic of the Catalytic Subunit of cAMP-dependent Protein Kinase  1q24: PKA double mutant model of PKB in complex with MgATP  1q61: PKA triple mutant model of PKB  1q62: PKA double mutant model of PKB  1q8t: The Catalytic Subunit of cAMP-dependent Protein Kinase (PKA) in Complex with Rho-kinase Inhibitor Y-27632  1q8u: The Catalytic Subunit of cAMP-dependent Protein Kinase in Complex with Rho-kinase Inhibitor H-1152P  1q8w: The Catalytic Subunit of cAMP-dependent Protein Kinase in Complex with Rho-kinase Inhibitor Fasudil (HA-1077)  1rdq: Hydrolysis of ATP in the crystal of Y204A mutant of cAMP-dependent protein kinase  1re8: Crystal structure of cAMP-dependent protein kinase complexed with balanol analog 2  1rej: Crystal structure of cAMP-dependent protein kinase complexed with balanol analog 1  1rek: Crystal structure of cAMP-dependent protein kinase complexed with balanol analog 8  1smh: Protein kinase A variant complex with completely ordered N-terminal helix  1stc: CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT IN COMPLEX WITH STAUROSPORINE  1sve: Crystal Structure of Protein Kinase A in Complex with Azepane Derivative 1  1svg: Crystal Structure of Protein Kinase A in Complex with Azepane Derivative 4  1svh: Crystal Structure of Protein Kinase A in Complex with Azepane Derivative 8  1syk: Crystal structure of E230Q mutant of cAMP-dependent protein kinase reveals unexpected apoenzyme conformation  1szm: DUAL BINDING MODE OF BISINDOLYLMALEIMIDE 2 TO PROTEIN KINASE A (PKA)  1veb: Crystal Structure of Protein Kinase A in Complex with Azepane Derivative 5  1xh4: Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants  1xh5: Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants  1xh6: Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants  1xh7: Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants  1xh8: Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants  1xh9: Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants  1xha: Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants  1ydr: STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT IN COMPLEX WITH H7 PROTEIN KINASE INHIBITOR 1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE  1yds: STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT IN COMPLEX WITH H8 PROTEIN KINASE INHIBITOR [N-(2-METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE  1ydt: STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT IN COMPLEX WITH H89 PROTEIN KINASE INHIBITOR N-[2-(4-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE  2c1a: STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY) ETHYLAMINO)ETHYL)AMIDE  2c1b: STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH (4R,2S)-5'-(4-(4-CHLOROBENZYLOXY)PYRROLIDIN-2-YLMETHANESULFONYL)ISOQUINOLINE  2cpk: CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CYCLIC ADENOSINE MONOPHOSPHATE-DEPENDENT PROTEIN KINASE  2erz: Crystal Structure of c-AMP Dependent Kinase (PKA) bound to hydroxyfasudil  2f7e: PKA complexed with (S)-2-(1H-Indol-3-yl)-1-(5-isoquinolin-6-yl-pyridin-3-yloxymethyl-etylamine  2f7x: Protein Kinase A bound to (S)-2-(1H-Indol-3-yl)-1-[5-((E)-2-pyridin-4-yl-vinyl)-pyridin-3-yloxymethyl]-ethylamine  2f7z: Protein Kinase A bound to (R)-1-(1H-Indol-3-ylmethyl)-2-(2-pyridin-4-yl-[1,7]naphtyridin-5-yloxy)-ehylamine  2gfc: cAMP-dependent protein kinase PKA catalytic subunit with PKI-5-24  2gnf: Protein kinase A fivefold mutant model of Rho-kinase with Y-27632  2gng: Protein kinase A fivefold mutant model of Rho-kinase  2gnh: PKA five fold mutant model of Rho-kinase with H1152P  2gni: PKA fivefold mutant model of Rho-kinase with inhibitor Fasudil (HA1077)  2gnj: PKA three fold mutant model of Rho-kinase with Y-27632  2gnl: PKA threefold mutant model of Rho-kinase with inhibitor H-1152P  2gu8: Discovery of 2-Pyrimidyl-5-Amidothiophenes as Novel and Potent Inhibitors for AKT: Synthesis and SAR Studies  2jds: STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH A-443654  2jdt: STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY) ETHYLAMINO)ETHYL) AMIDE  2jdv: STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH A-443654  2oh0: Crystal structure of Protein Kinase A in complex with Pyridine-Pyrazolopyridine Based Inhibitors  2ojf: Crystal structure of Protein Kinase A in complex with Pyridine-Pyrazolopyridine based inhibitors  2uvx: STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH 7-AZAINDOLE  2uvy: STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH METHYL-(4-(9H-PURIN-6-YL)-BENZYL)-AMINE  2uvz: STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH C-PHENYL-C-(4-(9H-PURIN-6-YL)-PHENYL)-METHYLAMINE  2uw0: STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH 6-(4-(4-(4-CHLORO-PHENYL)-PIPERIDIN-4-YL)-PHENYL)-9H-PURINE  2uw3: STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH 5-METHYL-4-PHENYL-1H-PYRAZOLE  2uw4: STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH 2-(4-(5-METHYL-1H-PYRAZOL-4-YL)-PHENYL)-ETHYLAMINE  2uw5: STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH (R)-2-(4-CHLORO-PHENYL)-2-(4-1H-PYRAZOL-4-YL)-PHENYL)-ETHYLAMINE  2uw6: STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH (S)-2-(4-CHLORO-PHENYL)-2-(4-1H-PYRAZOL-4-YL)-PHENYL)-ETHYLAMINE  2uw7: STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH 4-(4-CHLORO-PHENYL)-4-(4-(1H-PYRAZOL-4-YL)-PHENYL)-PIPERIDINE  2uw8: STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH 2-(4-CHLORO-PHENYL)-2-PHENYL-ETHYLAMINE  2uzt: PKA STRUCTURES OF AKT, INDAZOLE-PYRIDINE INHIBITORS  2uzu: PKA STRUCTURES OF INDAZOLE-PYRIDINE SERIES OF AKT INHIBITORS  2uzv: PKA STRUCTURES OF INDAZOLE-PYRIDINE SERIES OF AKT INHIBITORS  2uzw: PKA STRUCTURES OF INDAZOLE-PYRIDINE SERIES OF AKT INHIBITORS