PRKAG2

PRKAG2
Identifiers
Aliases	PRKAG2, AAKG, AAKG2, CMH6, H91620p, WPWS, protein kinase AMP-activated non-catalytic subunit gamma 2
External IDs	MGI: 1336153 HomoloGene: 136125 GeneCards: PRKAG2
Genetically Related Diseases
bipolar disorder, kidney disease[1]
Gene ontology Molecular function • nucleotide binding • ADP binding • AMP-activated protein kinase activity • protein kinase activator activity • phosphorylase kinase regulator activity • AMP binding • cAMP-dependent protein kinase regulator activity • cAMP-dependent protein kinase inhibitor activity • ATP binding • protein kinase binding Cellular component • cytosol • nucleoplasm • extracellular fluid • nucleotide-activated protein kinase complex Biological process • carnitine shuttle • intracellular signal transduction • sterol biosynthetic process • regulation of fatty acid oxidation • negative regulation of protein kinase activity • regulation of glucose import • lipid metabolic process • regulation of fatty acid biosynthetic process • fatty acid metabolic process • regulation of glycolytic process • protein phosphorylation • fatty acid biosynthetic process • positive regulation of peptidyl-threonine phosphorylation • regulation of fatty acid metabolic process • cell cycle arrest • ATP biosynthetic process • glycogen metabolic process • regulation of catalytic activity • macroautophagy • positive regulation of protein kinase activity • regulation of signal transduction by p53 class mediator • activation of protein kinase activity • negative regulation of protein serine/threonine kinase activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51422	108099
Ensembl	ENSG00000106617	ENSMUSG00000028944
UniProt	Q9UGJ0	Q91WG5
RefSeq (mRNA)	NM_001040633 NM_001304527 NM_001304531 NM_016203 NM_024429	NM_001170555 NM_001170556 NM_145401 NM_001310480
RefSeq (protein)	NP_001035723.1 NP_001291456.1 NP_001291460.1 NP_057287.2 NP_077747.1	NP_001164027.1 NP_663376.2
Location (UCSC)	Chr 7: 151.56 – 151.88 Mb	Chr 5: 24.86 – 25.1 Mb
PubMed search	[2]	[3]
Wikidata

5'-AMP-activated protein kinase subunit gamma-2 is an enzyme that in humans is encoded by the PRKAG2 gene.^[4][5][6]

Function

AMP-activated protein kinase (AMPK) is a heterotrimeric protein composed of a catalytic alpha subunit, a noncatalytic beta subunit, and a noncatalytic regulatory gamma subunit. Various forms of each of these subunits exist, encoded by different genes. AMPK is an important energy-sensing enzyme that monitors cellular energy status and functions by inactivating key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This gene is a member of the AMPK gamma subunit family and encodes a protein with four CBS domains. Mutations in this gene have been associated with ventricular pre-excitation (Wolff-Parkinson-White syndrome), progressive conduction system disease and cardiac hypertrophy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[6]

Interactions

PRKAG2 has been shown to interact with PRKAB2^[7] and PRKAB1.^[7]

References

Further reading

External links

• GeneReviews/NCBI/NIH/UW entry on Familial Hypertrophic Cardiomyopathy Overview