P2RY1

P2RY1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4XNV, 4XNW
Identifiers
Aliases	P2RY1, P2Y1, purinergic receptor P2Y1
External IDs	MGI: 105049 HomoloGene: 1926 GeneCards: P2RY1
Targeted by Drug
adenosine diphosphate, adenosine triphosphate, adenosine 3',5'-diphosphate, suramin[1]
Gene ontology Molecular function • A1 adenosine receptor binding • G-protein coupled receptor activity • scaffold protein binding • ADP binding • G-protein coupled purinergic nucleotide receptor activity • signal transducer activity • ADP-activated adenosine receptor activity • protein binding • protein heterodimerization activity • ATP-activated adenosine receptor activity • ATP binding • receptor activity Cellular component • cell body • integral component of membrane • postsynaptic membrane • membrane • plasma membrane • integral component of plasma membrane • cell surface • dendrite • basolateral plasma membrane • apical plasma membrane • mitochondrion • postsynaptic density Biological process • hemostasis • cellular response to organic cyclic compound • regulation of vasodilation • G-protein coupled receptor signaling pathway • adenosine receptor signaling pathway • positive regulation of protein phosphorylation • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway • eating behavior • positive regulation of cytosolic calcium ion concentration • response to mechanical stimulus • aging • regulation of receptor activity • negative regulation of norepinephrine secretion • signal transduction involved in regulation of gene expression • wound healing • G-protein coupled purinergic nucleotide receptor signaling pathway • phospholipase C-activating G-protein coupled receptor signaling pathway • cell surface receptor signaling pathway • positive regulation of inositol trisphosphate biosynthetic process • negative regulation of binding • positive regulation of ion transport • positive regulation of ERK1 and ERK2 cascade • sensory perception of pain • response to growth factor • positive regulation of penile erection • protein localization to plasma membrane • positive regulation of hormone secretion • relaxation of muscle • positive regulation of transcription from RNA polymerase II promoter • glial cell migration • signal transduction • blood coagulation • platelet activation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5028	18441
Ensembl	ENSG00000169860	ENSMUSG00000027765
UniProt	P47900	P49650
RefSeq (mRNA)	NM_002563	NM_001282016 NM_008772
RefSeq (protein)	NP_002554.1	NP_001268945.1 NP_032798.1
Location (UCSC)	Chr 3: 152.83 – 152.84 Mb	Chr 3: 61 – 61.01 Mb
PubMed search	[2]	[3]
Wikidata

P2Y purinoceptor 1 is a protein that in humans is encoded by the P2RY1 gene.^[4]

Function

The product of this gene, P2Y₁ belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.^[5]

See also

• P2Y receptor

References

Further reading

External links

• "P2Y Receptors: P2Y₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.