Antiprogestogen

An antiprogestogen, also called an antiprogesterone agent, or in the case of a synthetic compound, an antiprogestin, is a type of hormone antagonist which antagonizes or suppresses the action of progesterone in the body, a sex hormone that plays a role in the menstrual cycle and pregnancy. Antiprogestogens may stop some cancer cells from growing and they are being studied in the treatment of breast cancer. They are also used as abortifacients.

Examples of antiprogestogens include mifepristone (weak partial agonist) and aglepristone (full antagonist).[1][2]

Medical termination of pregnancy: mifepristone combined with a prostaglandin (e.g., gemeprost).

See also

References

  1. ↑ Spitz, IM. (Oct 2006). "Progesterone receptor antagonists.". Curr Opin Investig Drugs. 7 (10): 882–90. PMID 17086932.
  2. ↑ Tang, OS.; Ho, PC. (Dec 2006). "Clinical applications of mifepristone.". Gynecol Endocrinol. 22 (12): 655–9. doi:10.1080/09513590601005946. PMID 17162706.

External links

 This article incorporates public domain material from the U.S. National Cancer Institute document "Dictionary of Cancer Terms".



This article is issued from Wikipedia - version of the 11/23/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.