Mecigestone
| Identifiers | |
|---|---|
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| Synonyms | Pentarane B; 6α-Methyl-16α,17α-cyclohexanoprogesterone |
| CAS Number | 58212-84-3 |
| PubChem (CID) | 124372 |
| ChemSpider | 110790 |
| Chemical and physical data | |
| Formula | C26H38O2 |
| Molar mass | 382.588 g/mol |
| 3D model (Jmol) | Interactive image |
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Mecigestone, also known as pentarane B, as well as 6α-methyl-16α,17α-cyclohexanoprogesterone, 6α-methylcyclohexano[1',2';16,17]pregn-4-ene-3,20-dione, or 17α-acetyl-6α-methyl-16β,24-cyclo-21-norchol-4-en-3-one, is a steroidal progestin that was developed by the Zelinskii Institute of Organic Chemistry of the Russian Academy of Sciences and has been proposed for clinical use as a progestogen but has not been marketed.[1][2][3][4][5] It is the 6α-methylated analogue of pentarane A, which is also known as D'6-pentarane or pregna-D'6-pentarane.[5]
See also
References
- ↑ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 8–. ISBN 978-1-4757-2085-3.
- ↑ Fedyushkina, I. V.; Skvortsov, V. S.; Romero Reyes, I. V.; Levina, I. S. (2014). "Molecular docking and 3D-QSAR of 16α,17α-cycloalkanoprogesterone derivatives as ligands of the progesterone receptor". Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry. 8 (2): 168–176. doi:10.1134/S1990750814020048. ISSN 1990-7508.
- ↑ Kamernitzky AV, Levina IS, Kulikova LE, Ignatov VN, Korkhov VV, Nikitina GV, Terekhina AI (1982). "Pregna-D'-pentaranes - a new class of active gestagenes". J. Steroid Biochem. 16 (1): 61–7. PMID 7062740.
- ↑ Nazarov, A. K.; Zavarzin, I. V.; Nazarov, G. V.; Aksenov, A. V.; Levina, I. S. (2016). "Preparation and Bioavailability Evaluation of Micronized Steroidal Mecigestone Drug Substance". Pharmaceutical Chemistry Journal. 49 (10): 706–710. doi:10.1007/s11094-016-1357-6. ISSN 0091-150X.
- 1 2 Bhakta, Amrita; Herman, Michelle; Levina, Inna S.; Moudgil, V. K. (1993). "Interaction of cycloalkanoprogesterones with mammalian progesterone receptor: binding of pregna-D'-pentaranes in the calf uterine cytosol". Molecular and Cellular Biochemistry. 125 (2): 153–161. doi:10.1007/BF00936444. ISSN 0300-8177.
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