STX2

STX2
Identifiers
Aliases	STX2, EPIM, EPM, STX2A, STX2B, STX2C, syntaxin 2
External IDs	MGI: 108059 HomoloGene: 37559 GeneCards: STX2
Gene ontology Molecular function • protein dimerization activity • SNAP receptor activity • calcium-dependent protein binding • protein binding • SNARE binding Cellular component • integral component of membrane • intracellular membrane-bounded organelle • membrane • synaptic vesicle • plasma membrane • extracellular fluid • basolateral plasma membrane • SNARE complex • extracellular exosome • lamellipodium Biological process • cell differentiation • ectoderm development • synaptic vesicle fusion to presynaptic active zone membrane • response to hydroperoxide • acrosome reaction • vesicle docking • cornified envelope assembly • protein oligomerization • animal organ morphogenesis • regulation of blood coagulation • intracellular protein transport • vesicle-mediated transport • signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2054	13852
Ensembl	ENSG00000111450	ENSMUSG00000029428
UniProt	P32856	Q00262
RefSeq (mRNA)	NM_001980 NM_194356	NM_001286033 NM_001286034 NM_007941
RefSeq (protein)	NP_001971.2 NP_919337.1	n/a
Location (UCSC)	Chr 12: 130.79 – 130.84 Mb	Chr 5: 128.98 – 129.01 Mb
PubMed search	[1]	[2]
Wikidata

Syntaxin-2, also known as epimorphin, is a protein that in humans is encoded by the STX2 gene.^[3][4][5]

The product of this gene belongs to the syntaxin/epimorphin family of proteins. The syntaxins are a large protein family implicated in the targeting and fusion of intracellular transport vesicles. The product of this gene regulates epithelial-mesenchymal interactions and epithelial cell morphogenesis and activation. Alternatively spliced transcript variants encoding different isoforms have been identified.^[5] When the N terminus is on the cytosolic face it acts as a t-SNARE involved in intracellular vesicle docking and is called Syntaxin-2. When flipped inside out, i.e. N terminus hangs out on the extracellular surface (by some nonclassical secretion pathway) it acts as a versatile morphogen and is called epimorphin. This membrane protein enjoys the double choice of another form of topological alternatives of being targeted to either apical or basolateral surface of an epithelial cell in a regulated way depending on various contexts. When expressed by mesenchymal cells it can instruct epithelial morphogenesis at epithelial mesenchymal interfaces.

Interactions

STX2 has been shown to interact with SNAP-25,^[6][7] SNAP23,^{[7][8][9][10]} STXBP1^[6][11] and Syntaxin binding protein 3.^[11]

References

Further reading