Adaptor-related protein complex 2, alpha 1

AP2A1
Identifiers
Aliases AP2A1, ADTAA, AP2-ALPHA, CLAPA1, Adaptor-related protein complex 2, alpha 1, adaptor related protein complex 2 alpha 1 subunit
External IDs MGI: 101921 HomoloGene: 68997 GeneCards: AP2A1
Orthologs
Species Human Mouse
Entrez

160

11771

Ensembl

ENSG00000196961

ENSMUSG00000060279

UniProt

O95782

P17426

RefSeq (mRNA)

NM_014203
NM_130787

NM_001077264
NM_007458

RefSeq (protein)

NP_055018.2
NP_570603.2

NP_001070732.1
NP_031484.1

Location (UCSC) Chr 19: 49.77 – 49.81 Mb Chr 7: 44.9 – 44.93 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

AP-2 complex subunit alpha-1 is a protein that in humans is encoded by the AP2A1 gene.[3]

This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP2 adaptors) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. Alternative splicing of this gene results in two transcript variants encoding two different isoforms. A third transcript variant has been described, but its full length nature has not been determined.[4]

Interactions

Adaptor-related protein complex 2, alpha 1 has been shown to interact with DPYSL2[5] and NUMB.[5]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Robinson MS (April 1989). "Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins)". J Cell Biol. 108 (3): 833–42. doi:10.1083/jcb.108.3.833. PMC 2115374Freely accessible. PMID 2564002.
  4. "Entrez Gene: AP2A1 adaptor-related protein complex 2, alpha 1 subunit".
  5. 1 2 Nishimura, Takashi; Fukata Yuko; Kato Katsuhiro; Yamaguchi Tomoya; Matsuura Yoshiharu; Kamiguchi Hiroyuki; Kaibuchi Kozo (September 2003). "CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth". Nat. Cell Biol. England. 5 (9): 819–26. doi:10.1038/ncb1039. ISSN 1465-7392. PMID 12942088.

Further reading


This article is issued from Wikipedia - version of the 5/24/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.