SYT6
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Synaptotagmin-6 is a protein that in humans is encoded by the SYT6 gene.[4][5]
Synaptotagmins, such as SYT6, share a common domain structure that includes a transmembrane domain and a cytoplasmic region composed of 2 C2 domains. Some synaptotagmins are involved in synaptic membrane fusion, while others have a more general function in endocytosis. For further information on synaptotagmins, see MIM 185605.[supplied by OMIM][5]
References
- ↑ "Diseases that are genetically associated with SYT6 view/edit references on wikidata".
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Craxton M (Sep 2001). "Genomic analysis of synaptotagmin genes". Genomics. 77 (1–2): 43–9. doi:10.1006/geno.2001.6619. PMID 11543631.
- 1 2 "Entrez Gene: SYT6 synaptotagmin VI".
Further reading
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
- Roggero CM, Tomes CN, De Blas GA, et al. (2006). "Protein kinase C-mediated phosphorylation of the two polybasic regions of synaptotagmin VI regulates their function in acrosomal exocytosis". Dev. Biol. 285 (2): 422–35. doi:10.1016/j.ydbio.2005.07.007. PMID 16111671.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241
. PMID 12477932. - Michaut M, De Blas G, Tomes CN, et al. (2001). "Synaptotagmin VI participates in the acrosome reaction of human spermatozoa". Dev. Biol. 235 (2): 521–9. doi:10.1006/dbio.2001.0316. PMID 11437455.
- Perin MS (1996). "Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin". Biochemistry. 35 (43): 13808–16. doi:10.1021/bi960853x. PMID 8901523.
- Li C, Ullrich B, Zhang JZ, et al. (1995). "Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins". Nature. 375 (6532): 594–9. doi:10.1038/375594a0. PMID 7791877.
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