SLC41A3

SLC41A3
Identifiers
Aliases SLC41A3, SLC41A1-L2, solute carrier family 41 member 3
External IDs MGI: 1918949 HomoloGene: 23052 GeneCards: SLC41A3
Orthologs
Species Human Mouse
Entrez

54946

71699

Ensembl

ENSG00000114544

ENSMUSG00000030089

UniProt

Q96GZ6

Q921R8

RefSeq (mRNA)

NM_001008485
NM_001008486
NM_001008487
NM_001164475
NM_017836

NM_001037493
NM_027868

RefSeq (protein)

NP_001008485.1
NP_001008486.1
NP_001008487.1
NP_001157947.1
NP_001008486.1

NP_001032570.1
NP_082144.2

Location (UCSC) Chr 3: 126.01 – 126.1 Mb Chr 6: 90.6 – 90.65 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Solute carrier family 41, member 3 is a protein that in humans is encoded by the SLC41A3 gene.[3]

Model organisms

Model organisms have been used in the study of SLC41A3 function. A conditional knockout mouse line, called Slc41a3tm1a(KOMP)Wtsi[8][9] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[10][11][12]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[6][13] Twenty six tests were carried out on mutant mice and one significant abnormality was observed: homozygous mutants displayed abnormal locomotor coordination.[6]

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. ↑ "Entrez Gene: Solute carrier family 41, member 3". Retrieved 2011-09-28.
  4. ↑ "Salmonella infection data for Slc41a3". Wellcome Trust Sanger Institute.
  5. ↑ "Citrobacter infection data for Slc41a3". Wellcome Trust Sanger Institute.
  6. 1 2 3 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
  7. ↑ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  8. ↑ "International Knockout Mouse Consortium".
  9. ↑ "Mouse Genome Informatics".
  10. ↑ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410Freely accessible. PMID 21677750.
  11. ↑ Dolgin E (2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  12. ↑ Collins FS; Rossant J; Wurst W (2007). "A Mouse for All Reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  13. ↑ van der Weyden L; White JK; Adams DJ; Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837Freely accessible. PMID 21722353.

Further reading

  • Wabakken, T.; Rian, E.; Kveine, M.; Aasheim, H. C. (2003). "The human solute carrier SLC41A1 belongs to a novel eukaryotic subfamily with homology to prokaryotic MgtE Mg2+ transporters". Biochemical and Biophysical Research Communications. 306 (3): 718–724. doi:10.1016/S0006-291X(03)01030-1. PMID 12810078. 


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