SLC30A3

SLC30A3
Identifiers
Aliases SLC30A3, ZNT3, solute carrier family 30 member 3
External IDs MGI: 1345280 HomoloGene: 74470 GeneCards: SLC30A3
Orthologs
Species Human Mouse
Entrez

7781

22784

Ensembl

ENSG00000115194

ENSMUSG00000029151

UniProt

Q99726

P97441

RefSeq (mRNA)

NM_003459
NM_001318949
NM_001318950
NM_001318951

NM_011773

RefSeq (protein)

NP_003450.2
NP_001305878.1
NP_001305879.1
NP_001305880.1

NP_035903.2

Location (UCSC) Chr 2: 27.25 – 27.28 Mb Chr 5: 31.09 – 31.11 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc transporter 3 also known as solute carrier family 30 member 3 is a protein in humans that is encoded by the SLC30A3 gene.[3]

The SLC30A3 gene codes for the ZnT-3 SLC30A family membrane transport protein. ZnT-3 is required for the accumulation of zinc ions inside synaptic vesicles.[4] In mice, ZnT-3 is required for some forms of memory that depend on the hippocampus and the amygdala.[5] Zinc transport by ZnT-3 modulates memory formation by acting through the extracellular signal-regulated kinases signaling pathway.[6] Angiotensin II-induced senescence of vascular smooth muscle cells requires down-regulation of ZnT-3 and ZnT-10.[7]

See also

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. ↑ "Entrez Gene: Solute carrier family 30 (zinc transporter), member 3".
  4. ↑ Cole TB; Wenzel HJ; Kafer KE; Schwartzkroin PA; Palmiter RD (February 1999). "Elimination of zinc from synaptic vesicles in the intact mouse brain by disruption of the ZnT3 gene". Proc. Natl. Acad. Sci. U.S.A. 96 (4): 1716–21. doi:10.1073/pnas.96.4.1716. PMC 15571Freely accessible. PMID 9990090.
  5. ↑ Sindreu C; Storm DR (2011). "Modulation of neuronal signal transduction and memory formation by synaptic zinc". Front Behav Neurosci. 5: 68. doi:10.3389/fnbeh.2011.00068. PMC 3211062Freely accessible. PMID 22084630.
  6. ↑ Mott DD; Dingledine R (February 2011). "Unraveling the role of zinc in memory". Proc. Natl. Acad. Sci. U.S.A. 108 (8): 3103–4. doi:10.1073/pnas.1100323108. PMC 3044369Freely accessible. PMID 21321213.
  7. ↑ Patrushev N; Seidel-Rogol B; Salazar G (2012). "Angiotensin II requires zinc and downregulation of the zinc transporters ZnT3 and ZnT10 to induce senescence of vascular smooth muscle cells". PLoS ONE. 7 (3): e33211. doi:10.1371/journal.pone.0033211. PMC 3299759Freely accessible. PMID 22427991.


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