Prothionamide

Prothionamide
Clinical data


AHFS/Drugs.com	International Drug Names
ATC code	J04AD01 (WHO)
Identifiers
IUPAC name 2-propylpyridine-4-carbothioamide
CAS Number	14222-60-7^Y
PubChem (CID)	666418
ChemSpider	579891^N
UNII	76YOO33643^Y
ECHA InfoCard	100.034.615
Chemical and physical data
Formula	C₉H₁₂N₂S
Molar mass	180.271 g/mol
3D model (Jmol)	Interactive image
SMILES CCCc1cc(ccn1)C(=S)N
InChI InChI=1S/C9H12N2S/c1-2-3-8-6-7(9(10)12)4-5-11-8/h4-6H,2-3H2,1H3,(H2,10,12)^N Key:VRDIULHPQTYCLN-UHFFFAOYSA-N^N
^NY (what is this?) (verify)

Protionamide (or prothionamide) is a drug used in the treatment of tuberculosis.^[1]

It has also been tested for use in the treatment of leprosy.^[2]

References

↑ Wang F, Langley R, Gulten G, et al. (January 2007). "Mechanism of thioamide drug action against tuberculosis and leprosy". J. Exp. Med. 204 (1): 73–8. doi:10.1084/jem.20062100. PMC 2118422. PMID 17227913.
↑ Fajardo TT, Guinto RS, Cellona RV, Abalos RM, Dela Cruz EC, Gelber RH (March 2006). "A clinical trial of ethionamide and prothionamide for treatment of lepromatous leprosy". Am. J. Trop. Med. Hyg. 74 (3): 457–61. PMID 16525107.

Rifamycins/ RNA polymerase inhibitor	Rifampicin^# Rifabutin Rifapentine Rifalazil^§

Antifolates/DSI	Dapsone^# Acedapsone Aldesulfone sodium

ASA	4-Aminosalicylic acid^# (Calcium aminosalicylate Sodium aminosalicylate)

Aminoglycosides	Amikacin^# Capreomycin^# Kanamycin^# Streptomycin^#

Oxazolidone	Linezolid

Peptidoglycan layer	Alanine analogue: Cycloserine^#

Arabinogalactan layer	Ethylenediamine/arabinosyltransferase inhibitor: Ethambutol^# SQ109^†

Mycolic acid layer	Hydrazides/mycolic acid synth. inhibition: Isoniazid^# Thiocarbamides: Ethionamide^# Prothionamide Thiocarlide

Other/unknown

Combinations

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