FCGR2B

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2FCB, 3WJJ,%%s3WJL

Identifiers

Aliases

FCGR2B, CD32, CD32B, FCG2, FCGR2, IGFR2, Fc fragment of IgG receptor IIb

External IDs

MGI: 95499 HomoloGene: 2974 GeneCards: FCGR2B

Gene ontology
Molecular function	• protein binding • IgG binding • transmembrane signaling receptor activity
Cellular component	• integral component of membrane • plasma membrane • membrane • cytoplasm
Biological process	• viral process • immune response • signal transduction • regulation of immune response
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


2213


14130

Ensembl


ENSG00000072694


ENSMUSG00000026656

UniProt


P31994 P31995


P08101

RefSeq (mRNA)


NM_001002273 NM_001002274 NM_001002275 NM_001190828 NM_004001


NM_001077189 NM_010187

RefSeq (protein)

NP_001002273.1 NP_001002274.1 NP_001002275.1 NP_001177757.1 NP_003992.3
NP_963857.3


NP_034317.1

Location (UCSC)

Chr 1: 161.66 – 161.68 Mb

Chr 1: 170.96 – 170.98 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Low affinity immunoglobulin gamma Fc region receptor II-b is a protein that, in humans, is encoded by the FCGR2B gene. FCGR2B (CD32B) is a "low affinity" receptor for Immunoglobulin G (IgG). Mutation in the gene in humans leads to a lupus phenotype.^[3]^[4] The cytoplasmic part of this receptor contains an immunoreceptor tyrosine-based inhibitory motif, in contrast to the activating isoform, FCGR2A (CD32A).

Function

The inhibitory CD32B is expressed on B cells and myeloid dendritic cells.^[5] Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target for monoclonal antibody therapy for malignancies.^[6]^[7]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Qiu WQ, de Bruin D, Brownstein BH, Pearse R, Ravetch JV (Jun 1990). "Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination". Science. 248 (4956): 732–5. doi:10.1126/science.2139735. PMID 2139735.
↑ "Entrez Gene: FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)".
↑ Boruchov AM, Heller G, Veri MC, Bonvini E, Ravetch JV, Young JW (2005). "Activating and inhibitory IgG Fc receptors on human DCs mediate opposing functions". J Clin Invest. 115 (10): 2914–23. doi:10.1172/JCI24772. PMC 1201664. PMID 16167082. (Free full text)
↑ Rankin CT, Veri MC, Gorlatov S, Tuaillon N, Burke S, Huang L, Inzunza HD, Li H, Thomas S, Johnson S, Stavenhagen J, Koenig S, Bonvini E (2006). "CD32B, the human inhibitory Fc-γ receptor IIB, as a target for monoclonal antibody therapy of B-cell lymphoma". Blood. 108 (7): 2384–91. doi:10.1182/blood-2006-05-020602. PMID 16757681. (Free full text)
↑ Zhou P, Comenzo RL, Olshen AB, Bonvini E, Koenig S, Maslak PG, Fleisher M, Hoffman J, Jhanwar S, Young JW, Nimer SD, Boruchov AM (2008). "CD32B is highly expressed on clonal plasma cells from patients with systemic light-chain amyloidosis and provides a target for monoclonal antibody–based therapy". Blood. 111 (7): 3403–6. doi:10.1182/blood-2007-11-125526. PMC 2275009. PMID 18216299. (Free full text)

Tsuchiya N, Kyogoku C (2005). "Role of Fc gamma receptor IIb polymorphism in the genetic background of systemic lupus erythematosus: insights from Asia.". Autoimmunity. 38 (5): 347–52. doi:10.1080/08916930500123926. PMID 16227149.
Engelhardt W, Geerds C, Frey J (1990). "Distribution, inducibility and biological function of the cloned and expressed human beta Fc receptor II.". Eur. J. Immunol. 20 (6): 1367–77. doi:10.1002/eji.1830200624. PMID 2142460.
Seki T (1989). "Identification of multiple isoforms of the low-affinity human IgG Fc receptor.". Immunogenetics. 30 (1): 5–12. doi:10.1007/BF02421463. PMID 2526077.
Brooks DG, Qiu WQ, Luster AD, Ravetch JV (1989). "Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes.". J. Exp. Med. 170 (4): 1369–85. doi:10.1084/jem.170.4.1369. PMC 2189488. PMID 2529342.
Stuart SG, Simister NE, Clarkson SB, et al. (1990). "Human IgG Fc receptor (hFcRII; CD32) exists as multiple isoforms in macrophages, lymphocytes and IgG-transporting placental epithelium.". EMBO J. 8 (12): 3657–66. PMC 402048. PMID 2531080.
Stengelin S, Stamenkovic I, Seed B (1988). "Isolation of cDNAs for two distinct human Fc receptors by ligand affinity cloning.". EMBO J. 7 (4): 1053–9. PMC 454434. PMID 3402431.
Engelhardt W, Matzke J, Schmidt RE (1995). "Activation-dependent expression of low affinity IgG receptors Fc gamma RII(CD32) and Fc gamma RIII(CD16) in subpopulations of human T lymphocytes.". Immunobiology. 192 (5): 297–320. doi:10.1016/s0171-2985(11)80172-5. PMID 7649565.
D'Ambrosio D, Hippen KL, Minskoff SA, et al. (1995). "Recruitment and activation of PTP1C in negative regulation of antigen receptor signaling by Fc gamma RIIB1.". Science. 268 (5208): 293–7. doi:10.1126/science.7716523. PMID 7716523.
Warmerdam PA, van den Herik-Oudijk IE, Parren PW, et al. (1993). "Interaction of a human Fc gamma RIIb1 (CD32) isoform with murine and human IgG subclasses.". Int. Immunol. 5 (3): 239–47. doi:10.1093/intimm/5.3.239. PMID 8466861.
Bewarder N, Weinrich V, Budde P, et al. (1996). "In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation.". Mol. Cell. Biol. 16 (9): 4735–43. PMC 231474. PMID 8756631.
Sandilands GP, MacPherson SA, Burnett ER, et al. (1997). "Differential expression of CD32 isoforms following alloactivation of human T cells.". Immunology. 91 (2): 204–11. doi:10.1046/j.1365-2567.1997.00241.x. PMC 1363848. PMID 9227318.
De SK, Venkateshan CN, Seth P, et al. (1998). "Adenovirus-mediated human immunodeficiency virus-1 Nef expression in human monocytes/macrophages and effect of Nef on downmodulation of Fcgamma receptors and expression of monokines.". Blood. 91 (6): 2108–17. PMID 9490697.
Metes D, Ernst LK, Chambers WH, et al. (1998). "Expression of functional CD32 molecules on human NK cells is determined by an allelic polymorphism of the FcgammaRIIC gene.". Blood. 91 (7): 2369–80. PMID 9516136.
Sondermann P, Huber R, Jacob U (1999). "Crystal structure of the soluble form of the human fcgamma-receptor IIb: a new member of the immunoglobulin superfamily at 1.7 A resolution.". EMBO J. 18 (5): 1095–103. doi:10.1093/emboj/18.5.1095. PMC 1171201. PMID 10064577.
Muraille E, Bruhns P, Pesesse X, et al. (2000). "The SH2 domain containing inositol 5-phosphatase SHIP2 associates to the immunoreceptor tyrosine-based inhibition motif of Fc gammaRIIB in B cells under negative signaling.". Immunol. Lett. 72 (1): 7–15. doi:10.1016/S0165-2478(00)00162-0. PMID 10789675.
Pricop L, Redecha P, Teillaud JL, et al. (2001). "Differential modulation of stimulatory and inhibitory Fc gamma receptors on human monocytes by Th1 and Th2 cytokines.". J. Immunol. 166 (1): 531–7. doi:10.4049/jimmunol.166.1.531. PMID 11123333.
Lyden TW, Robinson JM, Tridandapani S, et al. (2001). "The Fc receptor for IgG expressed in the villus endothelium of human placenta is Fc gamma RIIb2.". J. Immunol. 166 (6): 3882–9. doi:10.4049/jimmunol.166.6.3882. PMID 11238632.
Bharadwaj D, Mold C, Markham E, Du Clos TW (2001). "Serum amyloid P component binds to Fc gamma receptors and opsonizes particles for phagocytosis.". J. Immunol. 166 (11): 6735–41. doi:10.4049/jimmunol.166.11.6735. PMID 11359830.
Jessup CF, Ridings J, Ho A, et al. (2001). "The Fc receptor for IgG (Fc gamma RII; CD32) on human neonatal B lymphocytes.". Hum. Immunol. 62 (7): 679–85. doi:10.1016/S0198-8859(01)00257-9. PMID 11423173.

PDB gallery

1fcg: ECTODOMAIN OF HUMAN FC GAMMA RECEPTOR, FCGRIIA

1h9v: HUMAN FC-GAMMA-RECEPTOR IIA (FCGRIIA), MONOCLINIC

2fcb: HUMAN FC GAMMA RECEPTOR IIB ECTODOMAIN (CD32)

External links

FCGR2B protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Proteins: clusters of differentiation (see also list of human clusters of differentiation)

1-50	CD1 a-c 1A 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50

51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100

101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150

151-200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200

201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249

251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299

301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

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FCGR2B

Function

See also

References

Further reading

External links