APRIL (protein)

TNFSF13
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases TNFSF13, APRIL, CD256, TALL-2, TALL2, TRDL-1, ZTNF2, UNQ383/PRO715, TNLG7B, tumor necrosis factor superfamily member 13
External IDs MGI: 1916833 HomoloGene: 56971 GeneCards: TNFSF13
Orthologs
Species Human Mouse
Entrez

8741

69583

Ensembl

ENSG00000161955

ENSMUSG00000089669

UniProt

O75888

Q9D777

RefSeq (mRNA)

NM_001159505
NM_023517

RefSeq (protein)

NP_001185552.1
NP_001185553.1
NP_003799.1
NP_742084.1
NP_742085.1

NP_001152977.1
NP_076006.2

Location (UCSC) Chr 17: 7.56 – 7.56 Mb Chr 11: 69.68 – 69.69 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

A proliferation-inducing ligand (APRIL), also known as tumor necrosis factor ligand superfamily member 13 (TNFSF13), is a protein of the TNF superfamily recognized by the cell surface receptor TACI.[3][4]

Nomenclature

In the cluster of differentiation terminology, APRIL is designated CD256.

Function

The protein encoded by this gene is a member of the tumor necrosis factor ligand (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vivo experiments suggest an important role for APRIL in the long-term survival of plasma cells in the bone marrow. Mice deficient in April showed a reduced ability to support plasma cell survival In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.[5]

Interactions

TNFSF13 has been shown to interact with TNFRSF13B[6] and B-cell activating factor.[7]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Hahne M, Kataoka T, Schröter M, Hofmann K, Irmler M, Bodmer JL, Schneider P, Bornand T, Holler N, French LE, Sordat B, Rimoldi D, Tschopp J (Sep 1998). "APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth". The Journal of Experimental Medicine. 188 (6): 1185–90. doi:10.1084/jem.188.6.1185. PMC 2212534Freely accessible. PMID 9743536.
  4. "Entrez Gene: TNFSF13 tumor necrosis factor (ligand) superfamily, member 13".
  5. Belnoue E, Pihlgren M, McGaha TL, Tougne C, Rochat AF, Bossen C, Schneider P, Huard B, Lambert PH, Siegrist CA (Mar 2008). "APRIL is critical for plasmablast survival in the bone marrow and poorly expressed by early-life bone marrow stromal cells". Blood. 111 (5): 2755–64. doi:10.1182/blood-2007-09-110858. PMID 18180376.
  6. Wu Y, Bressette D, Carrell JA, Kaufman T, Feng P, Taylor K, Gan Y, Cho YH, Garcia AD, Gollatz E, Dimke D, LaFleur D, Migone TS, Nardelli B, Wei P, Ruben SM, Ullrich SJ, Olsen HS, Kanakaraj P, Moore PA, Baker KP (Nov 2000). "Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS". The Journal of Biological Chemistry. 275 (45): 35478–85. doi:10.1074/jbc.M005224200. PMID 10956646.
  7. Roschke V, Sosnovtseva S, Ward CD, Hong JS, Smith R, Albert V, Stohl W, Baker KP, Ullrich S, Nardelli B, Hilbert DM, Migone TS (Oct 2002). "BLyS and APRIL form biologically active heterotrimers that are expressed in patients with systemic immune-based rheumatic diseases". Journal of Immunology. 169 (8): 4314–21. doi:10.4049/jimmunol.169.8.4314. PMID 12370363.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


This article is issued from Wikipedia - version of the 5/28/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.