Decoy receptor 2

TNFRSF10D
Identifiers
Aliases TNFRSF10D, CD264, DCR2, TRAIL-R4, TRAILR4, TRUNDD, tumor necrosis factor receptor superfamily member 10d
External IDs HomoloGene: 136778 GeneCards: TNFRSF10D
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

8793

n/a

Ensembl

ENSG00000173530

n/a

UniProt

Q9UBN6

n/a

RefSeq (mRNA)

NM_003840

n/a

RefSeq (protein)

NP_003831.2

n/a

Location (UCSC) Chr 8: 23.14 – 23.16 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

Decoy receptor 2 (DCR2), also known as TRAIL receptor 4 (TRAILR4) and tumor necrosis factor receptor superfamily member 10D (TNFRSF10D), is a human cell surface receptor of the TNF-receptor superfamily.[2][3][4]

Function

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplasmic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis.[4]

References

  1. "Human PubMed Reference:".
  2. Marsters SA, Sheridan JP, Pitti RM, Huang A, Skubatch M, Baldwin D, Yuan J, Gurney A, Goddard AD, Godowski P, Ashkenazi A (Feb 1998). "A novel receptor for Apo2L/TRAIL contains a truncated death domain". Curr Biol. 7 (12): 1003–6. doi:10.1016/S0960-9822(06)00422-2. PMID 9382840.
  3. Pan G, Ni J, Yu G, Wei YF, Dixit VM (Apr 1998). "TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling". FEBS Lett. 424 (1-2): 41–5. doi:10.1016/S0014-5793(98)00135-5. PMID 9537512.
  4. 1 2 "Entrez Gene: TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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