Difenamizole
 | |
| Names | |
|---|---|
| IUPAC name
2-(Dimethylamino)-N-(2,5-diphenylpyrazol-3-yl)propanamide | |
| Other names
Diphenamizole | |
| Identifiers | |
| 3D model (Jmol) | Interactive image |
| ChEMBL | ChEMBL2105587 |
| ChemSpider | 59123 |
| PubChem | 65695 |
| |
| |
| Properties | |
| C20H22N4O | |
| Molar mass | 334.42 g·mol−1 |
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Difenamizole (INN) (brand name Pasalin; former developmental code name AP-14) is a non-steroidal anti-inflammatory drug (NSAID) and analgesic of the pyrazolone group related to metamizole.[1] It has monoaminergic properties, including inhibition of monoamine oxidase, augmentation of pargyline-induced elevation of striatal dopamine levels, inhibition of K+-induced striatal dopamine release, and inhibition of the reuptake of dopamine.[2][3][4]
See also
References
- ↑ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 398–. ISBN 978-1-4757-2085-3.
- ↑ Secci, D.; Bolasco, A.; Chimenti, P.; Carradori, S. (2011). "The State of the Art of Pyrazole Derivatives as Monoamine Oxidase Inhibitors and Antidepressant/Anticonvulsant Agents". Current Medicinal Chemistry. 18 (33): 5114–5144. doi:10.2174/092986711797636090. ISSN 0929-8673.
- ↑ Kameyama T, Nabeshima T, Yoshida N, Yamaguchi K (1981). "Neurochemical studies of an analgesic, 1,3-diphenyl-5-(2-dimethylaminopropionamide)-pyrazole [difenamizole]". Res. Commun. Chem. Pathol. Pharmacol. 31 (1): 31–53. PMID 6454942.
- ↑ NABESHIMA, Toshitaka; YAMAGUCHI, Kazumasa; KAMEYAMA, Tsutomu (1978). "EFFECTS OF DIFENAMIZOLE ON CONTENT OF CATECHOLAMINES AND METABOLITES IN MOUSE BRAIN". The Japanese Journal of Pharmacology. 28 (4): 642–646. doi:10.1254/jjp.28.642. ISSN 0021-5198.
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