Nuciferine
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| Names | |
|---|---|
| IUPAC name
(6aR)-1,2-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline | |
| Other names
(R)-1,2-Dimethoxyaporphine | |
| Identifiers | |
475-83-2  | |
| 3D model (Jmol) | Interactive image |
| ChEMBL | ChEMBL464529  |
| ChemSpider | 9740 |
| PubChem | 3108374 |
| |
| |
| Properties | |
| C19H21NO2 | |
| Molar mass | 295.376 g/mol |
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| verify (what is ?) | |
| Infobox references | |
Nuciferine is an alkaloid found within the plants Nymphaea caerulea and Nelumbo nucifera. It has a profile of action associated with dopamine receptor blockade.[1] It induces sedation, hypothermia, ptosis, and (in higher doses) catalepsy; it inhibits spontaneous motor activity, conditioned avoidance response, amphetamine toxicity and stereotypy. Nuciferine may also potentiate morphine analgesia. The median lethal dose in mice is 289 mg/kg. It is structurally related to apomorphine.[2][3]
See also
References
- ↑ Farrell MS et al. (2016): "In Vitro and In Vivo Characterization of the Alkaloid Nuciferine", PLoS One. PMID 26963248
- ↑ Bhattacharya SK, Bose R, Ghosh P, Tripathi VJ, Ray AB, Dasgupta B (Sep 1978). "Psychopharmacological studies on (—)-nuciferine and its Hofmann degradation product atherosperminine". Psychopharmacology (Berl.). 59 (1): 29–33. doi:10.1007/BF00428026. PMID 100809.
- ↑ Spess, David L. Errors in Alkaloids of Nelumbo and Nymphaea species, 2011, academia.edu
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