Phosphodiesterase I

Phosphodiesterase I
Identifiers
EC number 3.1.4.1
CAS number 9025-82-5
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Phosphodiesterase I (EC 3.1.4.1, 5'-exonuclease, 5'-phosphodiesterase, 5'-nucleotide phosphodiesterase, oligonucleate 5'-nucleotidohydrolase, 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I, 5'-NPDase, 5'-PDase, 5'-PDE, 5'NPDE, alkaline phosphodiesterase, nucleotide pyrophosphatase/phosphodiesterase I, orthophosphoric diester phosphohydrolase, PDE I, phosphodiesterase, exonuclease I) is an enzyme with systematic name oligonucleotide 5'-nucleotidohydrolase.[1] This enzyme catalyses the following chemical reaction

Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides

Hydrolyses both ribonucleotides and deoxyribonucleotides. Has low activity towards polynucleotides.

See also

References

  1. Khorana, G.H. (1961). "Phosphodiesterases". In Boyer PD, Lardy H, Myrbäck K. The Enzymes. 5 (2nd ed.). New York: Academic Press. pp. 79–94.
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